267900-42-5

Basic information

• Product Name: 1-O-(2-propenyl)-6-O-(4-tolylsulfonyl)-α-D-glucose
• Synonyms: 1-O-(2-propenyl)-6-O-(4-tolylsulfonyl)-α-D-glucose
• CAS NO: 267900-42-5
• Molecular Weight: 374.412
• Mol File: 267900-42-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-O-(2-propenyl)-6-O-(4-tolylsulfonyl)-α-D-glucose(CAS DataBase Reference)
• NIST Chemistry Reference: 1-O-(2-propenyl)-6-O-(4-tolylsulfonyl)-α-D-glucose(267900-42-5)
• EPA Substance Registry System: 1-O-(2-propenyl)-6-O-(4-tolylsulfonyl)-α-D-glucose(267900-42-5)

Safety Data

• Hazardous Substances Data: 267900-42-5(Hazardous Substances Data)

Upstream product

• 93382-48-0 allyl 4,6-O-benzylidene-α-D-glucopyranoside 
• 2280-44-6 D-Glucose 
• 98-59-9 p-toluenesulfonyl chloride 
• 7464-56-4 1-O-allyl-α-D-glucopyranoside 
• 1122-58-3 dmap 

Downstream Products

• 1234307-20-0 C₅₄H₉₉IO₁₀SSi₃ 
• 1234307-22-2 C₅₂H₉₆IO₁₂SSi₃^(1-)*Na⁽¹⁺⁾ 
• 1234307-23-3 C₃₄H₅₄IO₁₂S^(1-)*Na⁽¹⁺⁾ 
• 1234307-24-4 C₅₄H₉₇I₃O₁₀SSi₃ 
• 1234307-25-5 C₅₂H₉₄I₃O₁₂SSi₃^(1-)*Na⁽¹⁺⁾ 
• 1234307-26-6 C₃₄H₅₂I₃O₁₂S^(1-)*Na⁽¹⁺⁾ 
• 265312-92-3 1-O-allyl-2,3,4-tri-O-(tert-butyldimethylsilyl)-6-O-(4-tolylsulfonyl)-α-D-glucopyranoside 

Relevant articles and documents

Synthesis of sulfoquinovosylacylglycerols, inhibitors of eukaryotic DNA polymerase α and β

Sulfoquinovosyldiacylglycerols (SQDGs) and sulfoquinovosylmonoacylglycerols (SQMGs), bearing diverse fatty acids, were synthesized from d-glucose, and were examined for enzymatic inhibitions of DNA polymerase α and β. These results indicated that the carbon numbers of the fatty acids were highly related to the activities, at least in vitro, of eukaryotic DNA polymerase inhibition.

Sulfoquinovosylacylglycerol derivative, and use thereof as medicaments

A method for immunosuppression in a subject comprising administering to the subject in need thereof, a pharmaceutically effective amount of at least one sulfoquinovosylacylglycerol derivative represented by General formula (1-1): wherein R101 represents an acyl residue of a higher fatty acid, and R102 represents a hydrogen atom or an acyl residue of a higher fatty acid; and a pharmaceutically acceptable salt thereof. Of the sulfoquinovosylacylglycerol derivatives, β-sulfoquinovosylacylglycerols are novel compounds. The present invention also relates to pharmaceutical composition comprising a pharmaceutically effective amount of the β-sulfoquinovosylacylglycerols and/or its pharmaceutically acceptable salt; and a pharmaceutically acceptable excipient. The pharmaceutical composition may be used as an immunosuppressive agent, anticancer agent and DNA polymerase α inhibitor.

Novel sulfoquinovosylacylglycerol derivative, and use thereof as medicaments

A method for immunosuppression in a subject comprising administering to the subject in need thereof, a pharmaceutically effective amount of at least one sulfoquinovosylacylglycerol derivative represented by General formula (1-1): wherein R101 represents an acyl residue of a higher fatty acid, and R102 represents a hydrogen atom or an acyl residue of a higher fatty acid; and a pharmaceutically acceptable salt thereof. Of the sulfoquinovosylacylglycerol derivatives, β-sulfoquinovosylacylglycerols are novel compounds. The present invention also relates to pharmaceutical composition comprising a pharmaceutically effective amount of the β-sulfoquinovosylacylglycerols and/or its pharmaceutically acceptable salt; and a pharmaceutically acceptable excipient. The pharmaceutical composition may be used as an immunosuppressive agent, anticancer agent and DNA polymerase α inhibitor.