268209-15-0

Basic information

• Product Name: (S)-tert-butyl 4-(4-(5-(aMinoMethyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)piperazine-1-carboxylate
• Synonyms: (S)-tert-butyl 4-(4-(5-(aMinoMethyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)piperazine-1-carboxylate
• CAS NO: 268209-15-0
• Molecular Formula: C₁₉H₂₇FN₄O₄
• Molecular Weight: 394.4404832
• Mol File: 268209-15-0.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-tert-butyl 4-(4-(5-(aMinoMethyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)piperazine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-tert-butyl 4-(4-(5-(aMinoMethyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)piperazine-1-carboxylate(268209-15-0)
• EPA Substance Registry System: (S)-tert-butyl 4-(4-(5-(aMinoMethyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)piperazine-1-carboxylate(268209-15-0)

Safety Data

• Hazardous Substances Data: 268209-15-0(Hazardous Substances Data)

Usage

Description

(S)-tert-butyl 4-(4-(5-(aMinoMethyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)piperazine-1-carboxylate is a complex chemical compound characterized by its intricate molecular structure. It features a piperazine ring, a fluorophenyl group, and an oxazolidin-3-yl moiety, among other functional groups. This carboxylate ester has a tert-butyl group attached to the piperazine nitrogen, and the presence of an aminomethyl group and an oxazolidin-3-yl ring indicates potential pharmacological activity. (S)-tert-butyl 4-(4-(5-(aMinoMethyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)piperazine-1-carboxylate's stereochemistry is specified as (S)-configuration at the tert-butyl carbon, contributing to its diverse range of molecular functionalities. This makes it a potentially interesting compound for further study and development in medicinal chemistry.

Uses

Used in Pharmaceutical Industry:
(S)-tert-butyl 4-(4-(5-(aMinoMethyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)piperazine-1-carboxylate is used as a potential drug or drug intermediate for its pharmacological activity due to the presence of an aminomethyl group and an oxazolidin-3-yl ring.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (S)-tert-butyl 4-(4-(5-(aMinoMethyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)piperazine-1-carboxylate is used as a subject of study and development because of its diverse molecular functionalities and (S)-configuration at the tert-butyl carbon, which may lead to novel therapeutic applications.

Upstream product

• 154590-62-2 (R)-tert-butyl-4-(2-fluoro-4-(5-(hydroxymethyl)-2-oxooxazolidin-3-yl)phenyl)piperazine-1-carboxylate 
• 154590-64-4 (S)-N-[3-[3-fluoro-4-[N-t-butoxycarbonylpiperazin-1-yl]phenyl]-2-oxooxazolidin-5-ylmethyl]azide 
• 154590-35-9 tert-butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate 
• 154590-34-8 4-(2-fluoro-4-nitrophenyl)-piperazine-1-carboxylic acid tert butyl ester 
• 154590-36-0 tert-butyl 4-(4-(benzyloxycarbonyl)-2-fluorophenyl)piperazine-1-carboxylate 
• 154590-63-3 [N-3-(1-tert-butoxycarbonyl)-4-(2-fluoro-4-piperazinyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate 
• 369-34-6 3,4-difluoronitrobenzene 
• 154590-33-7 1-(2-fluoro-4-nitrophenyl)piperazine 
• 874820-28-7 (5R)-[3-[3-fluoro-4-[N-t-butoxycarbonylpiperazin-1-yl]phenyl]-2-oxo-5-oxazolidinylmethyl] nosylate 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 348626-16-4 tert-butyl 4-{4-[(5S)-5-({[(5-chloro-2-thienyl)carbonyl]amino}methyl)-2-oxo-1,3-oxazolidin-3-yl]-2-fluorophenyl}piperazine-1-carboxylate 
• 154590-65-5 (S)-N-{[3-[3-fluoro-4-(N-4-tert-butoxycarbonylpiperazin-1-yl)phenyl]-2-oxo-5-oxazolidinyl]methyl}acetamide 
• 392659-24-4 N-(3-{3-fluoro-4-[4-(5-formyl-furan-2-ylmethyl)-piperazin-1-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide 
• 548762-76-1 N-(3-{3-fluoro-4-[4-(5-hydroxymethyl-furan-2-ylmethyl)-piperazin-1-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide 
• 548762-73-8 N-[3-(3-fluoro-4-{4-[5-(hydroxyimino-methyl)-furan-2-ylmethyl]-piperazin-1-yl}-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide 
• 154590-66-6 (S)-N-[[3-[3-fluoro-4-(1-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 
• 864665-17-8 C₂₁H₂₉FN₄O₆ 

Relevant articles and documents

RETRACTED ARTICLE: Design, synthesis of novel oxazolidino-amides/sulfonamides conjugates and their impact on antibacterial activity

Abstract: In view of generating new compounds for future drug development, we have synthesized oxazolidinones library of aryl amides and aryl sulfonamide derivatives. These compounds were screened in vitro against panel of susceptible and resistant Gram-p

Synthesis and antibacterial activities of N-substituted-glycinyl 1H-1,2,3-triazolyl oxazolidinones

A series of 1H-1,2,3-triazolyl piperazino oxazolidinone analogs with optionally varied glycinyl substitutions were synthesized and their antibacterial activity assessed against a panel of susceptible and resistant Gram-positive and selected Gram-negative

Novel and potent oxazolidinone antibacterials featuring 3-indolylglyoxamide substituents

Novel oxazolidinone antibacterials bearing a variety of 3-indolylglyoxamide substituents have been explored in an effort to improve the spectrum and potency of this class of agents. A subclass of this series was also made with the diversity at C-5 terminus. These derivatives have been screened against a panel of clinically relevant Gram-positive pathogens and fastidious Gram-negative organisms. Several analogs in this series were identified with in vitro activity superior to linezolid (MIC = 0.25-2 μg/mL). Compounds 10a, 10c, 10e and 10f displayed activity against linezolid resistant Gram-positive organisms (MIC = 2-4 μg/mL). Selected oxazolidinones were evaluated for in vivo efficacy against a mouse systemic infection model.