26845-57-8

Basic information

• Product Name: Allyl-4-cyclohexanon
• Synonyms: Allyl-4-cyclohexanon
• CAS NO: 26845-57-8
• Molecular Weight: 138.21
• Mol File: 26845-57-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Allyl-4-cyclohexanon(CAS DataBase Reference)
• NIST Chemistry Reference: Allyl-4-cyclohexanon(26845-57-8)
• EPA Substance Registry System: Allyl-4-cyclohexanon(26845-57-8)

Safety Data

• Hazardous Substances Data: 26845-57-8(Hazardous Substances Data)

Upstream product

• 20498-05-9 3-allylcyclohexanone 
• 26845-54-5 3-(1,4-dioxa-spiro[4.5]dec-8-yl)-propan-1-ol 
• 60739-53-9 4-(tetrahydro-2H-pyran-2-yloxy)cyclohexanone 
• 211995-75-4 4-methylene-1-(tetrahydropyran-2-yloxy)cyclohexane 
• 26845-56-7 4-(3-bromopropyl)cyclohexanone 
• 64230-40-6 4-(2-Tetrahydropyranyloxy)-1-cyclohexanol 
• 556-48-9 1,4-Cyclohexanediol 
• 934821-86-0 4-(tetrahydropyran-2-yloxy)cyclohexanemethanol 

Downstream Products

• 86437-33-4 (R)-2-Benzyl-3-oxa-2-aza-tricyclo[5.2.2.0^1,5]undecane 

Relevant articles and documents

Carbonyl 1,2-transposition through triflate-mediated a-amination

To date, it remains challenging to selectively migrate a carbonyl oxygen within a given molecular scaffold, especially to an adjacent carbon. In this work, we describe a simple one- or two-pot protocol that transposes a ketone to the vicinal carbon. This approach first converts the ketone to the corresponding alkenyl triflate, which can then undergo the palladium- and norbornene-catalyzed regioselective a-amination and ipso-hydrogenation enabled by a bifunctional hydrogen and nitrogen donor. The resulting "transposed enamine" intermediate can subsequently be hydrolyzed to produce the 1,2-carbonyl-migrated product. This method allows rapid access to unusual bioactive analogs through late-stage functionalization.