268733-18-2 Usage
Description
4-BROMO-3,5-BIS(TRIFLUOROMETHYL)ANILINE is an organic compound characterized by its unique molecular structure, featuring a bromo group at the 4th position and two trifluoromethyl groups at the 3rd and 5th positions on an aniline backbone. 4-BROMO-3,5-BIS(TRIFLUOROMETHYL)ANILINE is known for its potential applications in various chemical and pharmaceutical processes due to its distinct properties.
Uses
Used in Pharmaceutical Industry:
4-BROMO-3,5-BIS(TRIFLUOROMETHYL)ANILINE is used as a key intermediate in the synthesis of various pharmaceutical compounds for [application reason]. It plays a crucial role in the development of new drugs targeting specific diseases and conditions.
Used in Cancer Treatment:
4-BROMO-3,5-BIS(TRIFLUOROMETHYL)ANILINE is used as a precursor for synthesizing 2-hydroxydiarylamide derivatives, which are known to inhibit TMPRSS4 serine protease activity. This inhibition helps in suppressing cancer cell invasion, making it a valuable component in the development of anticancer drugs.
Used in Antitubercular Drug Development:
4-BROMO-3,5-BIS(TRIFLUOROMETHYL)ANILINE is also used in the synthesis of salicylanilides, which exhibit lantitubercular activities. These compounds are being investigated for their potential to treat tuberculosis, a significant global health concern.
Check Digit Verification of cas no
The CAS Registry Mumber 268733-18-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,8,7,3 and 3 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 268733-18:
(8*2)+(7*6)+(6*8)+(5*7)+(4*3)+(3*3)+(2*1)+(1*8)=172
172 % 10 = 2
So 268733-18-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H4BrF6N/c9-6-4(7(10,11)12)1-3(16)2-5(6)8(13,14)15/h1-2H,16H2
268733-18-2Relevant articles and documents
Discovery of novel 2-hydroxydiarylamide derivatives as TMPRSS4 inhibitors
Kang, Sunghyun,Min, Hye-Jin,Kang, Min-Seo,Jung, Myung-Geun,Kim, Semi
, p. 1748 - 1751 (2013/04/10)
TMPRSS4 is a novel type II transmembrane serine protease that has been implicated in the invasion and metastasis of colon cancer cells. In this study, a novel series of 2-hydroxydiarylamide derivatives were synthesized and evaluated for inhibiting TMPRSS4 serine protease activity and suppressing cancer cell invasion. These derivatives demonstrated good inhibitory activity against TMPRSS4 serine protease, which correlated with the promising anti-invasive activity of colon cancer cells overexpressing TMPRSS4.