2689-88-5Relevant articles and documents
Dimethyl 4,4-Bis(ethoxycarbonyl)-1,2-cyclopentanediylidenediacetate
Bocelli, Gabriele,Cantoni, Andrea,Costa, Mirco
, p. 2374 - 2376 (1995)
The title compound, C17H22O8, is an example of a product obtained from a cyclodicarbonylation reaction using diacetylenic substrates.The five-membered ring assumes a near-envelope conformation with the two acetate chains lying practically in the plane of the four coplanar ring atoms, C1, C2, C4 and C5, while the ethoxycarbonyl groups (attatched to the atom forming the 'flap') are oriented in opposite directions.The conjugated C=C-C=O chromophore systems are planar and are not parallel.Intramolecular interactions are in the range 2.43(3)-2.60(4) Angstroem.
A unique polymeric gel by thiol-alkyne click chemistry
Ganivada, Mutyala Naidu,Kumar, Pawan,Shunmugam, Raja
, p. 50001 - 50004 (2015)
Poly(ethylene glycol) functionalized with tetra-acetylene (PTETACT) and pentaerythritol (3-mercaptopropionic acid) (PETM) are cross-linked by a thiol-yne reaction to create robust, tuneable networks. A new class of unique gels is produced by gelations in various organic solvents as well as water. This is the first report of creating 3D gel networks by a thiol-alkyne reaction in the presence of triethylamine under moderate temperature.
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Eglinton,G. et al.
, p. 2597 - 2603 (1964)
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Epoxyanthracene Derivatives and Dicarbonylation on Benzene Ring via Hexadehydro-Diels-Alder (HDDA) Derived Benzynes with Oxazoles
Yang, Feihu,Zheng, Xiaojie,Lei, Yu,Hu, Qiong,Zhu, Wenjing,Hu, Yimin
supporting information, p. 1125 - 1133 (2021/11/22)
A capture reaction of hexadehydro-Diels-Alder (HDDA) derived benzyne with various substituted oxazoles is reported. With methyl, hydrogen, or phenyl as the substituent at 2-position of oxazole, tetraynes afforded epoxyanthracene derivatives or underwent dicarbonylation on benzene ring. The reaction does not require any catalyst or additive. The mechanism behind the reaction was investigated. The obtained polycyclic product structure has potential application value in optoelectronic materials. The availability of dicarbonylated arene implies the uniqueness of HDDA benzyne reaction compared with traditional benzyne.
1,6-heptadiynes based cyclopolymerization functionalized with mannose by post polymer modification for protein interaction
Das, Rituparna,Dash, Tapan K.,Kanjilal, Pintu,Kumar, Pawan,Le, Trong-Nghia,Mohanan, Manikandan,Mukhopadhyay, Balaram,Rao, N. Vijayakameswara,Shunmugam, Raja
, (2021/07/22)
Carbohydrate functionalized polymers or Glycopolymers have earned a great deal of interest in recent times for their potential biomedical applications. In the present study, a mannose containing glycopolymer was synthesized by cyclopolymerization of malonic acid derivative using second generation Hoveyda Grubbs′ catalyst. Post-polymerization modification was done to install a propargyl moiety. Finally, functionalization of the propargylated polymer with 2-azidoethyl mannoside using azide-alkyne “click chemistry” furnished the target glycopolymer which was successfully characterized using NMR, FT-IR, mass spectroscopy and advanced polymer chromatography. The glycopolymer was found to self-assemble into capsule and spherical shape in water and DMSO respectively and these morphologies were observed through SEM and TEM. Upon interaction with Con A, the mannose containing glycopolymer showed an increment in aggregation induced fluorescence with increasing concentration of the lectin. In vitro cytotoxicity studies on MCF 7 cell line showed 90% cell viability up to glycopolymer concentration of 500 μg/mL.
