26894-49-5

Basic information

• Product Name: ALTERNARIOL MONOMETHYL ETHER
• Synonyms: ALTERNARIOL MONOMETHYL ETHER;alternariol monomethyl ether from*alternaria alte;ALTERNARIOL MONOMETHYL ETHER FROMALTERNA RIA ALTERN;alternariol monomethyl ether from alternaria alternata (tenuis);Alternariol monomethyl ether 99%;3,7(3,9 or 7,9)-Dihydroxy-9(7 or 3)-Methoxy-1-Methyl-6H-dibenzo[b,d]pyran-6-one;Alternariol monomethyl ether/AME
• CAS NO: 26894-49-5
• Molecular Formula: C15H12O5
• Molecular Weight: 272.25
• Product Categories: Cell Signaling and Neuroscience;Mold;Toxins and Venoms;Inhibitors;Mutagenesis Research Chemicals;Inhibitor
• Mol File: 26894-49-5.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 559.169 °C at 760 mmHg
• Flash Point: 217.389 °C
• Appearance: /
• Density: 1.427 g/cm³
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• Stability: Hygroscopic
• CAS DataBase Reference: ALTERNARIOL MONOMETHYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: ALTERNARIOL MONOMETHYL ETHER(26894-49-5)
• EPA Substance Registry System: ALTERNARIOL MONOMETHYL ETHER(26894-49-5)

Safety Data

• Hazard Codes: T+
• Statements: 61-26/27/28
• Safety Statements: 53-22-36/37/39-45
• RIDADR: UN 2811 6.1/PG 1
• WGK Germany: 3
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 26894-49-5(Hazardous Substances Data)

Usage

Description

Alternariol monomethyl ether (AME) is an alternaria mycotoxin and genotoxin that is commonly found in edible crops. It is known for its ability to inhibit the activity of various DNA-topoisomerases, which leads to an increased rate of DNA strand breaks.

Uses

Used in Research and Development:
Alternariol monomethyl ether is used as a research compound for studying the effects of mycotoxins and genotoxins on DNA and cellular processes. Its ability to inhibit DNA-topoisomerases makes it a valuable tool for understanding the mechanisms of DNA damage and repair, as well as the potential carcinogenic properties of certain substances.
Used in Food Safety and Quality Control:
AME is used as a reference material in the development and validation of analytical methods for detecting and quantifying mycotoxins in the food supply. This helps ensure the safety and quality of food products by identifying and controlling the presence of harmful substances.
Used in Pharmaceutical Industry:
Alternariol monomethyl ether can be used as a starting material or a reference compound in the development of new drugs targeting DNA-topoisomerases, which are essential enzymes in DNA replication and transcription. Inhibiting these enzymes can have therapeutic applications in the treatment of certain diseases, including cancer.
Used in Environmental Monitoring:
AME can be employed as a biomarker for assessing the presence of mold contamination in various environments, such as indoor air quality, water sources, and agricultural settings. Monitoring the levels of Alternariol monomethyl ether can help identify potential health risks and guide appropriate remediation measures.