26921-44-8

Basic information

• Product Name: Methanone, (1-methylcyclopropyl)phenyl-
• Synonyms: 1-benzoyl-1-methylcyclopropane;1-Methyl-1-benzoyl-cyclopropan;(1-methyl-cyclopropyl)-phenyl ketone;Methanone,(1-methylcyclopropyl)phenyl;<1-Methyl-cyclopropyl>-phenyl-keton
• CAS NO: 26921-44-8
• Molecular Formula: C11H12O
• Molecular Weight: 160.216
• Mol File: 26921-44-8.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Methanone, (1-methylcyclopropyl)phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (1-methylcyclopropyl)phenyl-(26921-44-8)
• EPA Substance Registry System: Methanone, (1-methylcyclopropyl)phenyl-(26921-44-8)

Safety Data

• Hazardous Substances Data: 26921-44-8(Hazardous Substances Data)

Upstream product

• 68423-23-4 1-Brom-1-phenylspiropentan 
• 6914-76-7 1-Methyl-cyclopropanoic acid 
• 608537-49-1 N-methoxy-N,1-dimethylcyclopropane-1-carboxamide 
• 100-58-3 phenylmagnesium bromide 
• 16480-05-0 1-methylcyclopropanecarbonyl chloride 
• 769-60-8 2-methyl-1-phenylprop-2-en-1-one 
• 93-55-0 1-phenyl-propan-1-one 
• 100-42-5 styrene 
• 100-52-7 benzaldehyde 
• 75-11-6 diiodomethane 
• 71-43-2 benzene 
• 38111-44-3 phenylzinc(II) bromide 
• 58908-50-2 3-acetoxy-2,2-dimethylpropionyl chloride 
• 3481-02-5 cyclopropyl phenyl ketone 

Downstream Products

• 116215-96-4 (1-methylcyclopropyl)(phenyl)methanol 
• 51999-31-6 (R)-(+)-Phenyl-1,2,3-trimethyl-cyclopent-2-enyl-keton 
• 1140910-93-5 1-phenyl-2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-butanone 
• 594-11-6 methylcyclopropane 
• 55-21-0 benzamide 
• 937237-80-4 1-(1-Methyl-cyclopropyl)-1-phenyl-prop-2-yn-1-ol 
• 138354-28-6 [4-(4-Hydroxy-3-methyl-4-phenyl-butyl)-phenyl]-(1-methyl-cyclopropyl)-methanone 
• 138354-29-7 (4-{4-Hydroxy-4-[4-(4-hydroxy-3-methyl-4-phenyl-butyl)-phenyl]-3-methyl-butyl}-phenyl)-(1-methyl-cyclopropyl)-methanone 
• 77070-49-6 4-Iodo-2-methyl-1-phenyl-butan-1-one 

Relevant articles and documents

SUBSTITUTED 2-AMINO-PYRAZOLYL-[1,2,4]TRIAZOLO[1,5A] PYRIDINE DERIVATIVES AND USE THEREOF

Provided herein are 2-amino-pyrazolyl-[ 1,2,4]triazolo [1,5a]pyridine derivatives. Such compounds are useful, for example, for the treatment and/or prevention of neurodegenerative diseases or disorders such as ophthalmological neurodegenerative disorders. This disclosure also features compositions containing the same as well as methods of using and making the same.

N-Heterocyclic Carbene-Catalyzed Radical Relay Enabling Vicinal Alkylacylation of Alkenes

The N-heterocyclic carbene-catalyzed radical relay enables the vicinal alkylacylation of styrenes, acrylates and acrylonitrile using aldehydes and tertiary alkyl carboxylic acid-derived redox-active esters. This protocol introduces tertiary alkyl groups and acyl groups to C-C double bonds with complete regioselectivity to produce functionalized ketone derivatives. The radical relay mechanism involves single electron transfer from the enolate form of a Breslow intermediate and radical addition of the resultant alkyl radical to the alkene followed by radical-radical coupling.

Another Role of Copper in the SimmonsSmith Reaction: Copper-catalyzed Nucleophilic Michael-type Cyclopropanation of a,β-Unsaturated Ketones

Cyclopropanation was performed using the Furukawa procedure with CH2I2/Et2Zn and a,β-unsaturated ketones. The reaction was performed in the presence of a copper salt. The reactivity was highly dependent on the substrate structure, and cyclopropanated products were obtained in better yields than those achieved using the original SimmonsSmith conditions with a ZnCu couple in some cases. Stereospecificity was observed in a certain case; however, the synthesis of an asymmetric version with a chiral ligand was not successful.