269398-80-3 Usage
General Description
BOC-(R)-3-AMINO-4-(2-METHYL-PHENYL)-BUTYRIC ACID, also known as (R)-2-(tert-butoxycarbonylamino)-3-methyl-4-phenylbutanoic acid, is a compound used in the field of organic chemistry. It is a chiral compound with a BOC (tert-butoxycarbonyl) protecting group and an amino acid functional group, making it useful in peptide synthesis and pharmaceutical research. This chemical may also have potential applications in the development of new drugs and pharmaceuticals due to its unique properties and structure.
Check Digit Verification of cas no
The CAS Registry Mumber 269398-80-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,9,3,9 and 8 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 269398-80:
(8*2)+(7*6)+(6*9)+(5*3)+(4*9)+(3*8)+(2*8)+(1*0)=203
203 % 10 = 3
So 269398-80-3 is a valid CAS Registry Number.
InChI:InChI=1/C16H23NO4/c1-11-7-5-6-8-12(11)9-13(10-14(18)19)17-15(20)21-16(2,3)4/h5-8,13H,9-10H2,1-4H3,(H,17,20)(H,18,19)/t13-/m1/s1
269398-80-3Relevant articles and documents
Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors
Xu, Jinyou,Ok, Hyun O.,Gonzalez, Edward J.,Colwell Jr., Lawrence F.,Habulihaz, Bahanu,He, Huaibing,Leiting, Barbara,Lyons, Kathryn A.,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.,Parmee, Emma R.
, p. 4759 - 4762 (2007/10/03)
Modification of in-house screening lead β-aminoacyl proline 8 gave an equipotent thiazolidide 9. Extensive SAR studies on the phenyl ring of 9 led to the discovery of a novel series of potent and selective DP-IV inhibitors. Introduction of a fluorine at the 2-position proved to be crucial for the potency of this series. The 2,5-difluoro (22q) and 2,4,5-trifluoro (22t) analogues were potent inhibitors of DP-IV (IC50 = 270, 119 nM, respectively).
