269402-54-2

Basic information

• Product Name: N/[3-(dimethylamino)propyl]-4-{4-[bis(2-chloroethyl)amino]phenyl}-butyramide
• Synonyms: N/[3-(dimethylamino)propyl]-4-{4-[bis(2-chloroethyl)amino]phenyl}-butyramide
• CAS NO: 269402-54-2
• Molecular Weight: 388.381
• Mol File: 269402-54-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N/[3-(dimethylamino)propyl]-4-{4-[bis(2-chloroethyl)amino]phenyl}-butyramide(CAS DataBase Reference)
• NIST Chemistry Reference: N/[3-(dimethylamino)propyl]-4-{4-[bis(2-chloroethyl)amino]phenyl}-butyramide(269402-54-2)
• EPA Substance Registry System: N/[3-(dimethylamino)propyl]-4-{4-[bis(2-chloroethyl)amino]phenyl}-butyramide(269402-54-2)

Safety Data

• Hazardous Substances Data: 269402-54-2(Hazardous Substances Data)

Upstream product

• 109-55-7 1-amino-3-(dimethylamino)propane 
• 305-03-3 chlorambucil 
• 130198-76-4 methyl 3-<4-phenyl>butyrate 
• 20637-09-6 methyl 4-(4-aminophenyl)butanoate 
• 79481-83-7 methyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate 
• 5600-62-4 4-(4-nitrophenyl)butanoic acid 
• 5600-63-5 4-(4-nitrophenyl)butanoyl chloride 
• 17981-81-6 chlorambucil chloride 

Relevant articles and documents

Quaternary ammonium compounds

Compounds of formula corresponding to either formula (Ia) or (Ib): wherein: M represents a molecule that can be used for the treatment or diagnosis of pathologies caused by attack on the cartilage, R1, R2and R3represent an alkyl group, or R1, R2and R3, together with the nitrogen atom carrying them, form a heterocycle, X represents a (C1-C6)alkylene chain in which one or more —CH2— groups are optionally replaced by a sulphur atom, an oxygen atom, or an —NR—, —CO—, —CO—NH—, —CO2—, —SO— or —SO2— group, n represents 0 or 1, Hal represents a halogen atom, or, R4represents an alkyl group, Hal represents a halogen atom, represents a molecule that can be used for the treatment or diagnosis of pathologies caused by attack on the cartilage, wherein the nitrogen atom may optionally be included in a saturated or unsaturated nitrogen-containing heterocyclic system, or included in a double bond; and pharmaceutical compositions thereof.

Synthesis and in vitro evaluation of quaternary ammonium derivatives of chlorambucil and melphalan, anticancer drugs designed for the chemotherapy of chondrosarcoma

To enhance affinity for malignant cartilaginous tumors (chondrosarcomas), quaternary ammonium (QA) conjugates of chlorambucil and melphalan were prepared by linking the QA moiety to nitrogen mustards via an amide bond. They exhibited closely similar and s