26954-84-7

Basic information

• Product Name: 1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-4H-isoquinolin-3-one
• Synonyms: 1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-4H-isoquinolin-3-one
• CAS NO: 26954-84-7
• Molecular Weight: 355.39
• Mol File: 26954-84-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-4H-isoquinolin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-4H-isoquinolin-3-one(26954-84-7)
• EPA Substance Registry System: 1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-4H-isoquinolin-3-one(26954-84-7)

Safety Data

• Hazardous Substances Data: 26954-84-7(Hazardous Substances Data)

Upstream product

• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 

Downstream Products

• 492464-07-0 1-(3,4-dimethoxybenzyl)-2-carbamoylimidazol-1-yl-6,7-dimethoxy-1,2,3,4,tetrahydroisoquinoline 
• 41988-18-5 1-(3,4-dimethoxybenzyl)-2-chloroacetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 13074-31-2 Tetrahydropapaverine 

Relevant articles and documents

Synthesis and antispasmodic activity evaluation of bis-(papaverine) analogues

A new series of N-substituted bis-(tetrahydropapaverine) ring systems have been synthesised in expectation of better antispasmodic activity in comparison with papaverine. The synthesis of the targeted heterocycles is described along with a discussion of their structure activity relationship. The general synthetic methods of bis-(tetrahydropapaverine) analogues involve tetrahydropapaverine, various piperazines, diisocyanates and diisothiocyanates as starting materials. Pharmacological evaluation involves the in vitro antispasmodic activity on a freshly removed guinea pig ileum using a force displacement transducer amplifier connected to a physiograph. Among the analogues synthesized in the present study, N,N′-bis-[2-carbamoyl-1-(3,4- dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolinyl]piperazine (22), was found to be the most potent muscle relaxant (IC50: 0.31 μM).