26976-59-0

Basic information

• Product Name: 3-hydroxy-2,3-dihydro-1H-inden-1-one
• Synonyms: 3-Hydroxy-1-indanone
• CAS NO: 26976-59-0
• Molecular Formula: C₉H₈O₂
• Molecular Weight: 148.1586
• Mol File: 26976-59-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 296°C at 760 mmHg
• Flash Point: 124.7°C
• Density: 1.322g/cm³
• Vapor Pressure: 0.000667mmHg at 25°C
• Refractive Index: 1.635
• CAS DataBase Reference: 3-hydroxy-2,3-dihydro-1H-inden-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-2,3-dihydro-1H-inden-1-one(26976-59-0)
• EPA Substance Registry System: 3-hydroxy-2,3-dihydro-1H-inden-1-one(26976-59-0)

Safety Data

• Hazardous Substances Data: 26976-59-0(Hazardous Substances Data)

Upstream product

• 606-23-5 1H-indene-1,3(2H)-dione 
• 13167-95-8 1H-indene-1,2,3-trione 2-oxime 
• 40774-41-2 3-Bromoindan-1-one 
• 30385-41-2 3-Acetoxyindan-1-on 
• 111-34-2 -butyl vinyl ether 
• 84761-77-3 2-formylphenyl triflate 
• 60414-82-6 2,3-dihydro-1H-indene-1,3-diol 
• 6351-10-6 1-Indanol 
• 26452-98-2 2,3-dihydro-1H-inden-1-yl-acetate 
• 83-33-0 inden-1-one 
• 64-17-5 ethanol 
• 496-11-7 INDANE 
• 89-98-5 2-chloro-benzaldehyde 
• 1238625-83-6 3-(2-formylphenyl)-N-methyl-N-phenylpropiolamide 

Downstream Products

• 60414-82-6 2,3-dihydro-1H-indene-1,3-diol 
• 130999-32-5 1-Phenylindan-1,3-diol 
• 102325-53-1 spiro[imidazolidine-4,1'-indene]-2,5-dione 
• 606-23-5 1H-indene-1,3(2H)-dione 
• 41523-30-2 2-(p-diethylaminophenylmethylidene)-3-hydroxy-1-indanone 

Relevant articles and documents

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Protected indanones by a Heck-Aldol annulation reaction

Monoprotected 3-hydroxyindan-1-ones have been prepared in moderate to good yields by a new tandem reaction involving salicylaldehyde triflates and commercially available 2-hydroxyethyl vinyl ether. This one-pot annulation reaction proceeds in the presence of a palladium bidentate catalyst and results in the formation of two new ring systems.

N-Hydroxyphthalimide Anchored on Diamond Nanoparticles as a Selective Heterogeneous Metal-free Oxidation Catalyst of Benzylic Hydrocarbons and Cyclic Alkenes by Molecular O2

N-hydroxyphthalimide (NHPI) derived from trimellitic anhydride has been covalently anchored (4 wt %) through ester bonds to the surface of commercial diamond nanoparticles previously functionalized by chemical and thermal treatments (DH). IR spectroscopy of the NHPI/DH solid shows the presence of a characteristic peak at 1735 cm?1 attributable to the ester bond, while solid-state MAS 13C NMR spectroscopy shows two broad bands corresponding to carbon atoms of carbonyl groups (167 ppm) and aromatic carbons (127 ppm). NHPI/DH promotes autoxidation of isobutylbenzene involving superoxide (O2 .?) and hydroperoxide (HOO?) radicals; NHPI/DH can be reused at least three times and reach a minimum turnover number as high as 20 600, which is probably due to the inertness of the diamond surface, allowing free diffusion of reactive oxygen species. Analogous materials in which NHPI was anchored on activated carbon and multiwall carbon nanotubes were inefficient as autoxidation catalysts. NHPI/DH is able to promote also selective aerobic oxidation of other benzylic hydrocarbons and cycloalkenes.

SPIROCYCLIC HAT INHIBITORS AND METHODS FOR THEIR USE

Compounds having a structure of Formula (IX) or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b, R3a, R3b, R4a, R4b, Q1----Q2, R6, R7, A, B, W, x, and y are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various HAT-related conditions or diseases, including cancer, by administration of such compounds are also provided.