270065-74-2 Usage
General Description
Boc-(S)-3-Amino-4-(2-trifluoromethyl-phenyl)-butyric acid is a chemical compound that belongs to the class of amino acids. It consists of a butyric acid backbone with an amino group at the third position and a (S)-configuration. Additionally, it contains a 2-trifluoromethyl-phenyl moiety attached to the fourth carbon of the butyric acid. The Boc- group is a protecting group for the amino function, which can be removed under mild acidic conditions. Boc-(S)-3-Amino-4-(2-trifluoromethyl-phenyl)-butyric acid is commonly used in the synthesis of peptidomimetic drugs and peptides, as well as in the study of enzyme-substrate interactions and protein-ligand binding.
Check Digit Verification of cas no
The CAS Registry Mumber 270065-74-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,7,0,0,6 and 5 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 270065-74:
(8*2)+(7*7)+(6*0)+(5*0)+(4*6)+(3*5)+(2*7)+(1*4)=122
122 % 10 = 2
So 270065-74-2 is a valid CAS Registry Number.
InChI:InChI=1/C16H20F3NO4/c1-15(2,3)24-14(23)20-11(9-13(21)22)8-10-6-4-5-7-12(10)16(17,18)19/h4-7,11H,8-9H2,1-3H3,(H,20,23)(H,21,22)/t11-/m0/s1
270065-74-2Relevant articles and documents
Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors
Xu, Jinyou,Ok, Hyun O.,Gonzalez, Edward J.,Colwell Jr., Lawrence F.,Habulihaz, Bahanu,He, Huaibing,Leiting, Barbara,Lyons, Kathryn A.,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.,Parmee, Emma R.
, p. 4759 - 4762 (2007/10/03)
Modification of in-house screening lead β-aminoacyl proline 8 gave an equipotent thiazolidide 9. Extensive SAR studies on the phenyl ring of 9 led to the discovery of a novel series of potent and selective DP-IV inhibitors. Introduction of a fluorine at the 2-position proved to be crucial for the potency of this series. The 2,5-difluoro (22q) and 2,4,5-trifluoro (22t) analogues were potent inhibitors of DP-IV (IC50 = 270, 119 nM, respectively).
