270073-00-2

Basic information

• Product Name: 3-methyl-2-(4-nitrophenylsulphonamido)butanoic acid
• Synonyms: 3-methyl-2-(4-nitrophenylsulphonamido)butanoic acid
• CAS NO: 270073-00-2
• Molecular Weight: 302.308
• Mol File: 270073-00-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 3-methyl-2-(4-nitrophenylsulphonamido)butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-2-(4-nitrophenylsulphonamido)butanoic acid(270073-00-2)
• EPA Substance Registry System: 3-methyl-2-(4-nitrophenylsulphonamido)butanoic acid(270073-00-2)

Safety Data

• Hazardous Substances Data: 270073-00-2(Hazardous Substances Data)

Upstream product

• 72-18-4 L-valine 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 

Downstream Products

• 270072-06-5 (S)-2-[Benzyl-(4-nitro-benzenesulfonyl)-amino]-3-methyl-butyric acid 
• 852853-21-5 N^α-nosyl-L-valine chloride 
• 103478-58-6 Fmoc-N-methylvaline 
• 852853-12-4 N-(N-(N-nosyl-L-valyl)-N-methyl-L-isoleucyl)-L-alanine methyl ester 
• 852853-11-3 N-(N-(N-nosyl-L-valyl)-N-methyl-D-phenylalanyl)-L-alanine methyl ester 
• 852853-10-2 N-(N-(N-nosyl-L-valyl)-N-methyl-L-phenylalanyl)-L-alanine methyl ester 
• 1208119-44-1 N-nosyl-L-valine phenacyl ester 
• 1220527-23-0 N-nosyl-L-valine benzhydryl ester 

Relevant articles and documents

Synthesis, characterization and in vitro antitrypanosomal activities of new carboxamides bearing quinoline moiety

The reported toxicities of current antitrypanosomal drugs and the emergence of drug resistant trypanosomes underscore the need for the development of new antitrypanosomal agents. We report herein the synthesis and antitrypanosomal activity of 24 new amide derivatives of 3-aminoquinoline, bearing substituted benzenesulphonamide. Nine of the new derivatives showed comparable antitrypanosomal activities at IC50 range of 1–6 nM (melarsoprol 5 nM). Compound 11n and 11v are more promising antitrypanosomal agents with IC50 1.0 nM than the rest of the reported derivatives. The novel compounds showed satisfactory predicted physico-chemical properties including oral bioavailability, permeability and transport properties.

Novel anti-inflammatory and analgesic agents: synthesis, molecular docking and in vivo studies

Twelve new derivatives of benzothiazole bearing benzenesulphonamide and carboxamide were synthesised and investigated for their in vivo anti-inflammatory, analgesic and ulcerogenic activities. Molecular docking showed an excellent binding interaction of t

New carboxamide derivatives bearing benzenesulphonamide as a selective COX-II inhibitor: Design, synthesis and structure-activity relationship

Sixteen new carboxamide derivatives bearing substituted benzenesulphonamide moiety (7a-p) were synthesized by boric acid mediated amidation of appropriate benzenesulphonamide with 2-amino-4-picoline and tested for anti-inflammatory activity. One compound 7c showed more potent anti-inflammatory activity than celecoxib at 3 h in carrageenan-induced rat paw edema bioassay. Compounds 7g and 7k also showed good anti-inflammatory activity comparable to celecoxib. Compound 7c appeared selectivity index (COX-2/COX-1) better than celecoxib. Compound 7k appeared selectivity index (COX-2/COX-1) a little higher than the half of celecoxib while compound 7g is non-selective for COX-2. The LD50 of compounds 7c, 7g and 7k were comparable to celecoxib.