270082-22-9 Usage
Description
(S)-2-TETRAHYDROISOQUINOLINE ACETIC ACID HYDROCHLORIDE is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes. Its unique chemical structure allows it to be a versatile building block in the development of new compounds with potential applications in different industries.
Uses
Used in Pharmaceutical Industry:
(S)-2-TETRAHYDROISOQUINOLINE ACETIC ACID HYDROCHLORIDE is used as an active pharmaceutical intermediate for the development of new drugs. Its role in the synthesis of various medications makes it a valuable component in the pharmaceutical sector, contributing to the creation of innovative treatments for various health conditions.
Used in Agrochemical Industry:
In the agrochemical industry, (S)-2-TETRAHYDROISOQUINOLINE ACETIC ACID HYDROCHLORIDE is used as an important organic intermediate. It plays a key role in the development of new agrochemical products, such as pesticides and fertilizers, which are essential for maintaining agricultural productivity and ensuring food security.
Used in Dyestuff Industry:
(S)-2-TETRAHYDROISOQUINOLINE ACETIC ACID HYDROCHLORIDE is also utilized as a vital organic intermediate in the dyestuff industry. Its chemical properties make it suitable for the synthesis of various dyes and pigments, which are used in a wide range of applications, including textiles, plastics, and printing inks.
Check Digit Verification of cas no
The CAS Registry Mumber 270082-22-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,7,0,0,8 and 2 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 270082-22:
(8*2)+(7*7)+(6*0)+(5*0)+(4*8)+(3*2)+(2*2)+(1*2)=109
109 % 10 = 9
So 270082-22-9 is a valid CAS Registry Number.
InChI:InChI=1/C11H13NO2.ClH/c13-11(14)6-10-5-8-3-1-2-4-9(8)7-12-10;/h1-4,10,12H,5-7H2,(H,13,14);1H/t10-;/m0./s1
270082-22-9Relevant articles and documents
1-BENZYLSPIRO[PIPERIDINE-4,1′-PYRIDO[3,4-b]indole] ‘co-potentiators’ for minimal function CFTR mutants
Son, Jung-Ho,Phuan, Puay-Wah,Zhu, Jie S.,Lipman, Elena,Cheung, Amy,Tsui, Ka Yi,Tantillo, Dean J.,Verkman, Alan S.,Haggie, Peter M.,Kurth, Mark J.
, (2020/10/26)
We previously identified a spiro [piperidine-4,1-pyrido [3,4-b]indole] class of co-potentiators that function in synergy with existing CFTR potentiators such as VX-770 or GLGP1837 to restore channel activity of a defined subset of minimal function cystic fibrosis transmembrane conductance regulator (CFTR) mutants. Here, structure-activity studies were conducted to improve their potency over the previously identified compound, 20 (originally termed CP-A01). Targeted synthesis of 37 spiro [piperidine-4,1-pyrido [3,4-b]indoles] was generally accomplished using versatile two or three step reaction protocols with each step having high efficiency. Structure-activity relationship studies established that analog 2i, with 6′-methoxyindole and 2,4,5-trifluorobenzyl substituents, had the greatest potency for activation of N1303K-CFTR, with EC50 ～600 nM representing an ～17-fold improvement over the original compound identified in a small molecule screen.
