270088-53-4

Basic information

• Product Name: Acridine, 3-chloro-9-[(4-nitrophenyl)thio]-
• CAS NO: 270088-53-4
• Molecular Formula: C19H11ClN2O2S
• Molecular Weight: 366.828
• Mol File: 270088-53-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Acridine, 3-chloro-9-[(4-nitrophenyl)thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acridine, 3-chloro-9-[(4-nitrophenyl)thio]-(270088-53-4)
• EPA Substance Registry System: Acridine, 3-chloro-9-[(4-nitrophenyl)thio]-(270088-53-4)

Safety Data

• Hazardous Substances Data: 270088-53-4(Hazardous Substances Data)

Upstream product

• 118-91-2 ortho-chlorobenzoic acid 
• 13278-36-9 N-(3-chlorophenyl)anthranilic acid 
• 108-42-9 3-chloro-aniline 
• 62-53-3 aniline 
• 19218-88-3 N-phenyl-4-chloroanthranilic acid 
• 50-84-0 2,4 dichlorobenzoic acid 
• 6269-27-8 3-chloroacridin-9(10H)-one 
• 95112-15-5 6-Chloro-9-thioacridone 
• 586-78-7 para-nitrophenyl bromide 

Relevant articles and documents

Quantitative analysis of structure-activity relationship in the acridine serie part 1: Antiparasitic 9-thioaryl-acridine derivatives

Synthesis and antiparasitic activity vs T. cruzi and L. donovani of a series of 9-thioaryl acridines are reported. A convenient correlation between molecular structure and biological activity is proposed. Results not only agree with the classical interactions of acridines with DNA but also suggest possible role of charge transfer complexes.

Structure-trypanodical activity relationships

A set of 9-thioalkylacridinones, has been prepared and investigated' in vitro' against T. cruzi. Structure-antiparasitic activity relationships are detailed with a view to identify the major structural parameters for the activity under consideration.