27012-26-6Relevant articles and documents
SYNTHESIS OF ALKYL-SUBSTITUTED PYRIDINES FROM CO, C2H4, H2, and NH3 ON HETEROGENEOUS CATALYSTS
Kosolapova, B. S.,Levin, D. Z.,Sominskii, S. D.,Rar, L. F.,Mortikov, E. S.,Lapidus, A. L.
, p. 2244 - 2248 (1990)
The reaction of preparation of alkyl-substituted pyridines by hydroformylation of ethylene in the presence of ammonia on heterogeneous Rh-containing catalysts with the formation of 2-ethyl-3,5-dimethylpyridine (I) as the basic product with up to 70-80percent conversion of gases and up to an 80 wt. percent concentration of the basic product was investigated.The dependence of the activity and selectivity of the catalysts on the concentration of Rh and nature of the support was determined.A correlation between the activity of the catalysts and their acid properties was established by IR spectroscopy.
Some Nucleophilic Addition Reactions of 2,5-Dihydropyridines: Synthesis of 2,3,6-Trialkyl(phenyl)-1,2,3,6-tetrahydropyridines and 2,3,6-Trialkyl(phenyl)pyridines
Francis, Robert F.,Howell, Howard M.,Fetzer, Donald T.
, p. 2213 - 2215 (2007/10/02)
A series of 2,5-dialkyl(phenyl)-2,5-dihydropyridines (2) was prepared by reacting 1-lithio-2-alkyl(phenyl)-1,2-dihydropyridines (1) with alkyl halides.The 2,5-dihydropyridines (2) are stable when maintained cold under a nitrogen atmosphere, and these compounds react with alkyl(phenyl)lithium compounds by nucleophilic addition to the C=N moiety.The resultant products are 2,3,6-trialkyl(phenyl)-1,2,3,6-tetrahydropyridines (4) which can be oxidized (selenium) to the corresponding 2,3,6-trialkylpyridines (5).
