270585-04-1Relevant articles and documents
Novel retinoic acid receptor α agonists: Syntheses and evaluation of pyrazole derivatives
Kikuchi, Kouichi,Hibi, Shigeki,Yoshimura, Hiroyuki,Tai, Kenji,Hida, Takayuki,Tokuhara, Naoki,Yamauchi, Toshihiko,Nagai, Mitsuo
, p. 619 - 622 (2007/10/03)
We have designed and synthesized a series of pyrazole derivatives as candidate retinoic acid receptor (RAR) agonists. One of them, 4-[5-(1, 5-diisopropyl-1H-3-pyrazolyl)-1H-2-pyrrolyl]benzoic acid (11b), which possesses a 2,5-disubstituted pyrrole moiety, showed selective transactivation activity for the RARα receptor, and had highly potent cell-differentiating activity on HL-60 cells. (C) 2000 Elsevier Science Ltd. All rights reserved.