27065-95-8

Basic information

• Product Name: tris-(N-methylindol-3-yl)methane
• Synonyms: tris-(N-methylindol-3-yl)methane
• CAS NO: 27065-95-8
• Molecular Formula: C₂₈H₂₅N₃
• Molecular Weight: 404
• Mol File: 27065-95-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 264-266 °C
• Boiling Point: 627.8±50.0 °C(Predicted)
• Appearance: /
• Density: 1.18±0.1 g/cm3(Predicted)
• CAS DataBase Reference: tris-(N-methylindol-3-yl)methane(CAS DataBase Reference)
• NIST Chemistry Reference: tris-(N-methylindol-3-yl)methane(27065-95-8)
• EPA Substance Registry System: tris-(N-methylindol-3-yl)methane(27065-95-8)

Safety Data

• Hazardous Substances Data: 27065-95-8(Hazardous Substances Data)

Upstream product

• 603-76-9 1-methylindole 
• 487-89-8 Indole-3-carboxaldehyde 

Relevant articles and documents

NH4Cl-promoted synthesis of symmetrical and unsymmetrical triindolylmethanes under solvent-free conditions

The synthesis of various triindolylmethanes from indole-3-carboxaldehyde, using indole derivatives as reactants and NH4Cl as catalyst under solvent-free conditions, is described. This methodology provides access to both symmetrical and unsymmetrical triindolylmethanes in excellent yields. With N-methylindole particularly, indole-3-carboxaldehyde appears to act as a formyl donor, leading to the exclusive formation of a symmetrically trisubstituted product. The novelty of the methodology lies in its operational simplicity, environment friendly reaction conditions, and inexpensive and easy availability of the catalyst. A plausible mechanism of formation of the products is suggested.