271-58-9 Usage
Description
2,1-Benzisoxazole is a heterocyclic compound belonging to the benzoxazole family, characterized by the fusion of a benzene ring to a 1,2-oxazole ring across positions 3 and 4. It is a clear yellow to brown-red liquid and is formed through the thermal decomposition of anthranil, which produces aniline and cyclopentadiene carbonitrile. The surface-enhanced Raman spectrum of anthranil in activated silver colloid has been studied, providing insights into the chemical properties of 2,1-Benzisoxazole.
Uses
Used in Pharmaceutical Industry:
2,1-Benzisoxazole is used as a key intermediate for the synthesis of various pharmaceutical compounds due to its unique chemical structure and properties. Its ability to form stable complexes with other molecules makes it a valuable building block in the development of new drugs.
Used in Chemical Synthesis:
2,1-Benzisoxazole is used as a versatile building block in organic synthesis for the creation of a wide range of chemical compounds. Its unique structure allows for various functional group modifications, making it a valuable component in the synthesis of complex organic molecules.
Used in Material Science:
2,1-Benzisoxazole is used as a component in the development of novel materials with specific properties, such as improved stability, reactivity, or selectivity. Its unique chemical structure contributes to the overall performance of these materials, making it an important component in material science research and development.
Used in Research and Development:
2,1-Benzisoxazole is used as a research tool in the study of various chemical reactions and processes, as well as in the development of new synthetic methods and techniques. Its unique properties and reactivity make it an important compound for researchers in the field of chemistry and related disciplines.
Check Digit Verification of cas no
The CAS Registry Mumber 271-58-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 2,7 and 1 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 271-58:
(5*2)+(4*7)+(3*1)+(2*5)+(1*8)=59
59 % 10 = 9
So 271-58-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H5NO/c1-2-4-7-6(3-1)5-9-8-7/h1-5H
271-58-9Relevant articles and documents
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Bamberger
, p. 814 (1924)
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The Elimination of Masses 27 and 28 from the + Ion of 2-Nitrotoluene
Herbert, C. G.,Larka, E. A.,Beynon, J. H.
, p. 306 - 310 (1984)
The expulsion of neutral fragments of masses 27 and 28 from metastable + ions derived from 2-nitrotoluene has been observed.The relative abundances of the resulting fragment ions, together with the kinetic energy released in each process, has been compared with similar fragmentations of + ions derived from other precursor molecules.In this way, the nature of the neutral fragments and the structure of the + ions from 2-nitrotoluene has been investigated.The most likely structure is the 1,2-benzisoxazolenium cation although the coexistence of other structures cannot be ruled out on the present evidence.
Metal-Free [3+2] Annulation of Ynamides with Anthranils to Construct 2-Aminoindoles
Zhang, Jingyi,Li, Ying,Zhang, Chaofeng,Wang, Xiao-Na,Chang, Junbiao
supporting information, p. 2029 - 2035 (2021/04/05)
A novel metal-free [3+2] annulation of ynamides with anthranils provides a facile, flexible, environmentally friendly, and atom-economical route to 2-aminoindoles. This synthetic process proceeds with efficiency, excellent regioselectivity, and wide functional group tolerance under mild conditions. Moreover, the obtained 2-aminoindole products represent a multifunctional platform for the construction of various 2-aminoindolyl frameworks.
I2-DMSO mediated oxidative amidation of methyl ketones with anthranils for the synthesis of: α -ketoamides
Zhuang, Shi-Yi,Tang, Yong-Xing,Chen, Xiang-Long,Wu, Yan-Dong,Wu, An-Xin
supporting information, p. 4258 - 4262 (2021/05/31)
An I2-DMSO mediated oxidative amidation of methyl ketones using anthranils as masked N-nucleophiles has been developed for the direct synthesis of α-ketoamides with high atom-economy. This metal-free process involves reductive N-O bond cleavage of anthranils and oxidative C-N bond formation of methyl ketones under mild conditions. The iodo group and electrophilic formyl group provide multiple possibilities for further functionalization of α-ketoamides.
