2713-69-1Relevant articles and documents
Indoxyl-based umpolung strategy for the synthesis of unsymmetrical 3,3′-biindoles
Guo, Jing,Weng, Jiang,Huang, Gong-Bin,Huang, Lin-Jie,Chan, Albert S.C.,Lu, Gui
supporting information, p. 5493 - 5496 (2016/11/19)
3,3′-Bisindoles are known to be important structural motifs found in bioactive natural products, pharmaceuticals, and functional materials. Herein, a novel indoxyl-based approach was established for the synthesis of unsymmetrical 3,3′-biindoles from indoles and indoxyls. This approach generated moderate to excellent yields of the desired products (24 examples, up to 98% yield). The present method features broad substrate scope, operational simplicity, high atom economy, and utilization of non-toxic and inexpensive molecular iodine as catalyst. The applicability of this method has been demonstrated by the facile gram-scale synthesis.
5,5′-substituted indirubin-3′-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity
Choi, Soo-Jeong,Lee, Jung-Eun,Jeong, Soon-Young,Im, Isak,Lee, So-Deok,Lee, Eun-Jin,Lee, Sang Kook,Kwon, Seong-Min,Ahn, Sang-Gun,Yoon, Jung-Hoon,Han, Sun-Young,Kim, Jae-Il,Kim, Yong-Chul
experimental part, p. 3696 - 3706 (2010/08/06)
To enhance the ability of indirubin derivatives to inhibit CDK2/cyclin E, a target of anticancer agents, we designed and synthesized a new series of indirubin-3′-oxime derivatives with combined substitutions at the 5 and 5′ positions. A molecular docking
