2719-05-3

Basic information

• Product Name: 4,4'-DIACETAMIDODIPHENYLMETHANE
• Synonyms: 4,4'-DIACETAMIDODIPHENYLMETHANE;N,N-Acetyl MDA~Bis(4-acetamidophenyl)methane~4,4-Methylenedibenzamide;Bis(4-acetamidophenyl)methane~4,4'-Methylenedibenzamide;N,N'-AcetylMDA;4,4''-DIACETAMIDODIPHENYLMETHANE 98%;N-[4-(4-acetamidobenzyl)phenyl]acetamide;N-[4-[(4-acetamidophenyl)methyl]phenyl]acetamide;N-[4-[(4-acetamidophenyl)methyl]phenyl]ethanamide
• CAS NO: 2719-05-3
• Molecular Formula: C₁₇H₁₈N₂O₂
• Molecular Weight: 282.34
• Product Categories: Inhibitors
• Mol File: 2719-05-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 227-228 °C
• Boiling Point: 564.6°Cat760mmHg
• Flash Point: 217.8°C
• Appearance: /
• Density: 1.201g/cm³
• Storage Temp.: 2-8°C
• Solubility: Soluble in DMSO (up to 30 mg/ml)
• PKA: 14.73±0.70(Predicted)
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
• CAS DataBase Reference: 4,4'-DIACETAMIDODIPHENYLMETHANE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-DIACETAMIDODIPHENYLMETHANE(2719-05-3)
• EPA Substance Registry System: 4,4'-DIACETAMIDODIPHENYLMETHANE(2719-05-3)

Safety Data

• Hazard Codes: N
• Statements: 50/53
• Safety Statements: 60-61
• Hazardous Substances Data: 2719-05-3(Hazardous Substances Data)

Usage

Description

4,4'-DIACETAMIDODIPHENYLMETHANE is an organic compound with the molecular formula C15H15N2O2. It is a white crystalline solid that is soluble in organic solvents. It is used in various applications due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
4,4'-DIACETAMIDODIPHENYLMETHANE is used as an intermediate in the synthesis of various pharmaceutical compounds. It is particularly useful in the production of drugs that target specific receptors or enzymes in the body.
Used in Chemical Industry:
4,4'-DIACETAMIDODIPHENYLMETHANE is used as a building block in the synthesis of various organic compounds. Its unique structure allows it to be used in the creation of a wide range of molecules with different properties and applications.
Used in Research and Development:
4,4'-DIACETAMIDODIPHENYLMETHANE is used as a research compound in the development of new drugs and materials. Its unique chemical properties make it a valuable tool for studying various biological and chemical processes.
Used in Cosmetics Industry:
4,4'-DIACETAMIDODIPHENYLMETHANE is used as an additive in the cosmetics industry. It is used to improve the texture, stability, and performance of various cosmetic products.

References

1) Shan?et al. (2013),?Identification of small molecules for human hepatocyte expansion and iPS differentiation; Nat. Chem. Biol., 9 514

Upstream product

• 108-24-7 acetic anhydride 
• 101-77-9 4,4'-diamino diphenyl methane 
• 64-19-7 acetic acid 
• 50-00-0 formaldehyd 
• 103-84-4 Acetanilid 
• 1888-33-1 N-acetyl-(4-methylbenzene)sulfonamide 
• 14168-44-6 MEDINA 
• 7664-93-9 sulfuric acid 
• 142-04-1 aniline hydrochloride 
• 4522-92-3 4,4'-(Hydroxymethylen)-bis-acetanilid 
• 75-05-8 acetonitrile 

Downstream Products

• 50296-99-6 4,4'-bis(acetamido)benzophenone 
• 19014-15-4 bis-(4-acetylamino-3-nitro-phenyl)-methane 
• 184170-01-2 bis-(4-acetylamino-3-bromo-phenyl)-methane 
• 104-04-1 N-(4-Nitrophenyl)acetamide 
• 17474-44-1 3,3'-dinitro-4,4'-diaminodiphenylmethane 
• 611-98-3 4,4'-diaminobenzophenone 
• 5329-22-6 4,4'-Diamino-3,3'-dibromo-diphenylmethane 
• 5398-61-8 4,4'-diamino-3,3'-dibromo-benzophenone 
• 101-77-9 4,4'-diamino diphenyl methane 

Relevant articles and documents

Amide exchange reaction: A simple and efficient CuO catalyst for diacetamide synthesis

A highly copper-catalysed amide exchange reaction of hexamethylenediamine (HDA) with CH3CN and H2O for the synthesis of hexamethylenebisacetamide (HMBA) without an organic solvent or gas protection was developed. 100% HDA conversion and >99% HMBA selectivity was obtained. X-ray diffraction, scanning emission microscopy, and temperature-programmed reduction of hydrogen were used to characterize the structural properties of the catalyst. The reaction mechanism was also investigated.

Synthetic and mechanistic aspects of acid-catalyzed disproportionation of dialkyl diarylmethyl ethers: A combined experimental and theoretical study

The disproportionation reactions of various dialkyl diarylmethyl ethers have been carried out in the presence of a catalytic amount (10 mol-%) of o-benzenedisulfonimide as a Bronsted acid catalyst; the reaction conditions were mild, and the yields of the diarylmethane target products were good. The catalyst was easily recovered and purified, ready to be used in further reactions. The theoretical study confirmed that the reaction proceeds in two steps: The formation of a carbocation from the protonated ether followed by hydride transfer. Although the hydride transfer is the rate-determining step, it is the stability of the carbocation that determines the reaction rate and therefore the yields.

Acrylic acid heterocyclic amides, fungicidal compositions and use

Compounds of the formula STR1 wherein A, B, R1, X and Q are substituents of various types, and acid addition salts thereof. The compounds are useful as fungicides.