2719-14-4

Basic information

• Product Name: N-(4-methyl-3-nitrophenyl)acetamide
• Synonyms: N-(4-methyl-3-nitrophenyl)acetamide;3'-Nitro-4'-methylacetoanilide;3'-Nitro-p-acetotoluidide;N-(3-Nitro-4-methylphenyl)acetamide;N-(4-methyl-3-nitro-phenyl)ethanamide;2-Nitro-4-acetaMidotoluene;NSC 202380;NSC 86673
• CAS NO: 2719-14-4
• Molecular Formula: C₉H₁₀N₂O₃
• Molecular Weight: 194.1873
• EINECS: 220-319-0
• Product Categories: Aromatics
• Mol File: 2719-14-4.mol
• Article Data: 14

Chemical Properties

• Melting Point: 100-100.5°C
• Boiling Point: 370°Cat760mmHg
• Flash Point: 177.6°C
• Appearance: /
• Density: 1.289g/cm³
• Vapor Pressure: 1.14E-05mmHg at 25°C
• Refractive Index: 1.605
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.21±0.70(Predicted)
• CAS DataBase Reference: N-(4-methyl-3-nitrophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methyl-3-nitrophenyl)acetamide(2719-14-4)
• EPA Substance Registry System: N-(4-methyl-3-nitrophenyl)acetamide(2719-14-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 2719-14-4(Hazardous Substances Data)

Usage

Description

N-(4-methyl-3-nitrophenyl)acetamide, also known as 3-Methyl-4-nitro-N-acetylbenzeneamine (CAS# 2719-14-4), is an organic compound with a distinctive orange crystalline solid appearance. It is primarily recognized for its utility in the field of organic synthesis, where it serves as a valuable intermediate for the creation of various complex molecules and pharmaceuticals.

Uses

Used in Organic Synthesis:
N-(4-methyl-3-nitrophenyl)acetamide is used as a synthetic intermediate for the production of a wide range of organic compounds. Its unique molecular structure, featuring a nitro group and an acetamide group attached to a methylated phenyl ring, allows it to participate in various chemical reactions, facilitating the synthesis of target molecules with specific properties and applications.
Used in Pharmaceutical Industry:
Within the pharmaceutical industry, N-(4-methyl-3-nitrophenyl)acetamide is utilized as a building block for the development of novel drugs. Its reactivity and structural diversity make it a promising candidate for the creation of new therapeutic agents, potentially targeting a variety of medical conditions.
Used in Chemical Research:
N-(4-methyl-3-nitrophenyl)acetamide also finds application in chemical research, where it can be employed to study reaction mechanisms, explore new synthetic routes, and investigate the properties of related compounds. Its distinct chemical characteristics make it a valuable tool for advancing scientific understanding in the field of chemistry.

InChI:InChI=1/C9H10N2O3/c1-6-3-4-8(10-7(2)12)5-9(6)11(13)14/h3-5H,1-2H3,(H,10,12)

Upstream product

• 112842-34-9 4-N-acetylamino-2-amino-6-nitrotoluene 
• 108-24-7 acetic anhydride 
• 119-32-4 4-Methyl-3-nitroanilin 
• 64-19-7 acetic acid 
• 103-89-9 4-Methylacetanilide 
• 121-14-2 2,4-dinitrotoluene 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 
• 347909-29-9 N-(4-methyl-3-nitro-phenyl)-N'-phenyl-thiourea 
• 7732-18-5 water 
• 6629-29-4 2,4-diamino-6-dinitrotoluene 
• 7142-91-8 4-acetylamino-2,6-dinitrotoluene 
• 452291-15-5 C₉H₁₀N₂O₃ 
• 75-05-8 acetonitrile 

Downstream Products

• 610-36-6 4-amino-2-nitrobenzoic acid 
• 70343-10-1 2,5-dinitro-4-methylaniline 
• 70343-09-8 2,3-dinitro-4-methylaniline 
• 21573-29-5 4-acetylamino-2-nitrobenzoic acid 
• 6375-16-2 2-amino-4-acetylaminotoluene 
• 160088-65-3 4'-methyl-2',3'-dinitroacetanilide 
• 198992-85-7 acetic acid-(4-methyl-2,5-dinitro-anilide) 
• 119-32-4 4-Methyl-3-nitroanilin 
• 56185-24-1 4-methyl-3-nitro-diacetanilide 
• 5367-26-0 3-chloro-2-nitrotoluene 
• 56433-00-2 3-chloro-2-nitrobenzyl bromide 
• 84228-46-6 4-amino-2-nitrobenzoic acid ethyl ester 
• 602-01-7 1-methyl-2,3-dinitrobenzene 
• 109565-24-4 (5-amino-2-methyl-phenyl)-(4-dimethylamino-phenyl)-diazene 

Relevant articles and documents

Aryl imidazole derivative and application thereof

The invention relates to an aryl imidazole derivative and application thereof. The aryl imidazole derivative is a compound shown as a formula (I) in the description or pharmaceutically acceptable salt thereof. The invention also discloses application of the aryl imidazole derivative in preparation of drugs for treating cancers. The invention further discloses application of the aryl imidazole derivative in preparation of drugs for treating diseases caused by EGFR mutation.

Selective N-acetylation of aromatic amines using acetonitrile as acylating agent

A method for N-acetylation of amines has been developed using acetonitrile as an acylating agent and in situ generated trimethylsilyl iodide as the catalyst under microwave heating condition. The reaction is selective toward aromatic amines while aliphatic amines remain intact. The process eliminates the requirement of toxic acylating reagents like acetic anhydride and acetyl chloride.

The novel usage of thiourea nitrate in aryl nitration

Thiourea nitrate (TN) was easily prepared from thiourea and nitric acid to explore its use as a new nitration reagent. Nitrations of various aromatic compounds utilizing TN in concentrated sulfuric acid were studied. TN could convert aromatic compounds to the corresponding nitrated derivatives with various abnormal yields under mild conditions. The results suggested that the reaction mechanism might be different from those of traditional nitration reagents.