27200-12-0 Usage
Description
Dihydromyricetin (DHM), also known as ampelopsin, is a natural flavonoid compound found in significant quantities in certain Asian plant species, particularly Hovenia dulcis. This plant has been utilized in traditional Chinese medicine for centuries as a remedy for alcohol poisoning and hangovers. DHM is also commercially available as a supplement, often marketed to alleviate hangover symptoms due to its capacity to lower blood alcohol levels and its potential hepatoprotective properties. Research has demonstrated that DHM possesses a range of health benefits, including antimicrobial, anti-inflammatory, antioxidative, anticancer, and lipid and glucose metabolism-regulatory activities. Moreover, it mediates cell death with minimal adverse effects on normal cells and has been shown to offer substantial hepatoprotective effects, particularly in the context of alcohol-induced and other liver diseases.
Uses
Used in Pharmaceutical Applications:
Dihydromyricetin is used as a supplement for treating hangovers, attributed to its ability to reduce blood alcohol levels and its hepatoprotective properties.
Used in Anticancer Applications:
Dihydromyricetin is used as an anticancer agent, particularly in studying its antitumor activity against liver cancer cells.
Used in Metabolic Regulation:
Dihydromyricetin is used as a regulator for lipid and glucose metabolism, potentially benefiting individuals with related health conditions.
Used in Antimicrobial Applications:
Dihydromyricetin is used as an antimicrobial agent, leveraging its natural ability to combat harmful microorganisms.
Used in Anti-inflammatory Applications:
Dihydromyricetin is used as an anti-inflammatory agent, potentially aiding in the reduction of inflammation in the body.
Used in Antioxidative Applications:
Dihydromyricetin is used as an antioxidant, helping to neutralize harmful free radicals and protect cells from oxidative damage.
Used in Hepatoprotective Applications:
Dihydromyricetin is used as a hepatoprotective agent, providing significant protection to the liver, especially in cases of alcohol-induced and other liver diseases.
Used in Cell Death Mediation:
Dihydromyricetin is used in the mediation of cell death, particularly in the context of cancer treatment, where it can target cancerous cells with minimal adverse effects on normal cells.
benefits
Dihydromyricetin (DHM) relieves alcohol toxicity and prevents intoxication by limiting the absorption of alcohol in the gastrointestinal tract and promoting the metabolisation of alcohol in the liver. DHM is a promising compound for kidney protection, liver protection, and neurological protection when drinking alcohol.DHM benefits can include things like:relieve hangoverrelieve anxietycardioprotective propertiesprotect the liver
Biochem/physiol Actions
Dihydromyricetin (Ampelopsin) is a flavanonol with antioxidant and anti-cancer activity, found to have anti-alcohol intoxication effects. Its anti-alcohol effects appear to be by its actions as a positive modulator of GABA-A receptors at the benzodiazepine site.
Side effects
Dihydromyricetin has been used in Asia for thousands of years as a hangover cure and anti-intoxication medicine and is considered safe for humans even in massive doses.In a DHM toxicity study, researchers failed to find any side-effects while giving mice massive doses of up to 22g/kg body weight.Acute toxicity tests showed that a single dose of oral SHE up to 22 g/kg did not result in any death or toxic side effects in mice during 14 days'observation.Conversions from rat to human pharmacology can be estimated using the HED ratio of 16%, giving DHM a safe upper limit dosage of 15.68g for a 70kg person.
Check Digit Verification of cas no
The CAS Registry Mumber 27200-12-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,2,0 and 0 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 27200-12:
(7*2)+(6*7)+(5*2)+(4*0)+(3*0)+(2*1)+(1*2)=70
70 % 10 = 0
So 27200-12-0 is a valid CAS Registry Number.
InChI:InChI=1/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1
27200-12-0Relevant articles and documents
Heterocycles. XXV. Sodium Borohydride Reduction of Flavanonols
Li, Shaoshun,Onda, Masayuki,Kagawa, Hitoshi,Kawase, Hiromi,Iguchi, Mieko,Harigaya, Yoshihiro
, p. 2029 - 2035 (2007/10/02)
Solvent effects on the stereochemistry in the sodium borohydride reduction of (+/-)-flavanonols have been examined.The effects observed for the (+/-)-flavanonols with 5-OMe in 2-propanol, dioxane and methanol are explainable by the differences between the steric interactions inherent in the product-like transition states A and B.It has been also found that 5-OAc peculiarly affects the stereochemistry in the reduction to produce the (+/-)-catechin-type compounds in a one-pot process.The solvent and temperature effects are examined using a model analogous to the above.
