27231-33-0

Basic information

• Product Name: 2H-Benzimidazole-2-thione,1,3-dihydro-4-methyl-(9CI)
• Synonyms: 2H-Benzimidazole-2-thione,1,3-dihydro-4-methyl-(9CI);2-MERCAPTO-4-METHYLBENZIMIDAZOLE;1,3-Dihydro-4-methyl-2H-benzimidazole-2-thione;4-methyl-1,3-dihydrobenzimidazole-2-thione;4-Methyl-1,3-dihydro-benzoimidazole-2-thione
• CAS NO: 27231-33-0
• Molecular Formula: C₈H₈N₂S
• Molecular Weight: 164.23
• Product Categories: BENZIMIDAZOLE
• Mol File: 27231-33-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 276.8±33.0 °C(Predicted)
• Appearance: /
• Density: 1.32±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 10.60±0.30(Predicted)
• CAS DataBase Reference: 2H-Benzimidazole-2-thione,1,3-dihydro-4-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Benzimidazole-2-thione,1,3-dihydro-4-methyl-(9CI)(27231-33-0)
• EPA Substance Registry System: 2H-Benzimidazole-2-thione,1,3-dihydro-4-methyl-(9CI)(27231-33-0)

Safety Data

• Hazardous Substances Data: 27231-33-0(Hazardous Substances Data)

Usage

Description

2H-Benzimidazole-2-thione,1,3-dihydro-4-methyl-(9CI) is a chemical compound with the molecular formula C9H9N3S. It is a derivative of benzimidazole and is commonly used in pharmaceutical research and drug development. 2H-Benzimidazole-2-thione,1,3-dihydro-4-methyl-(9CI) possesses potential medicinal properties and has been studied for its potential use in the treatment of various medical conditions. Its molecular structure and properties make it suitable for further investigation and potential application in the field of medicine and pharmacology.

Uses

Used in Pharmaceutical Research and Drug Development:
2H-Benzimidazole-2-thione,1,3-dihydro-4-methyl-(9CI) is used as a research compound for the development of new pharmaceuticals. Its unique molecular structure and potential medicinal properties make it a valuable candidate for the creation of novel therapeutic agents.
Used in Medical Treatments:
2H-Benzimidazole-2-thione,1,3-dihydro-4-methyl-(9CI) is used as a potential treatment for various medical conditions. Its medicinal properties are currently being studied to determine its efficacy and safety in treating specific diseases and disorders.
Used in Medicinal Chemistry:
2H-Benzimidazole-2-thione,1,3-dihydro-4-methyl-(9CI) is used as a building block in the synthesis of other pharmaceutical compounds. Its molecular structure allows for the development of new drugs with improved properties and therapeutic effects.
Used in Drug Discovery:
2H-Benzimidazole-2-thione,1,3-dihydro-4-methyl-(9CI) is used in the process of drug discovery to identify new therapeutic agents. Its potential medicinal properties make it a promising candidate for the development of innovative treatments for various diseases and conditions.

Upstream product

• 75-15-0 carbon disulfide 
• 2687-25-4 3-methyl-1,2-benzenediamine 
• 1147550-11-5 ammonium thiocyanate 
• 570-24-1 2-Methyl-6-nitroaniline 
• 137-26-8 Thiram 
• 128-04-1 sodium dimethyldithiocarbamate 
• 140-89-6 potassium ethyl xanthogenate 
• 84445-92-1 2-amino-6-methylacetanilide 
• 84445-89-6 1-acetyl-7-methyl-2-benzimidazolethiol 
• 59907-22-1 N-(2-methyl-6-nitrophenyl)acetamide 
• 82344-53-4 N,N-diacetyl-6-nitro-o-toluidine 

Downstream Products

• 170116-49-1 7-methyl-2-methylmercaptobenzimidazole 
• 106747-42-6 2-[[(4-methyl-1H-benzimidazol-2-yl)thio]methyl]benzenamine 
• 106747-06-2 2-[[(4-methyl-1H-benzimidazol-2-yl)sulfinyl]methyl]benzenamine 
• 4887-83-6 7-methyl-1H-benzo[d]imidazole 

Relevant articles and documents

Highly Diastereoselective Synthesis of Dihydro-benzoimidazo-[1,3]-thiazines via Electro-oxidative Selenocyclization of Thioallyl Benzoimidazoles

The current methodology reveals a green and proficient electro-oxidative tandem selenocyclization of thioallyl benzoimidazoles manufacturing selenylated dihydro-benzoimidazo-thiazine derivatives. Both C?Se and C?N bond formation were achieved via this mild protocol which exhibits good functional group tolerability affording an extensive range of substrate scope up to 96% isolated yields. Complete control over the regioselective formation of the six-membered heterocycle and stereoselective construction of the contiguous stereocenters was established. The practical electrochemical method operates in an undivided cell at ambient temperature without using any metal and external chemical oxidant.

AlCl3-Promoted Synthesis of 2-Mercapto Benzoheterocycles by Using Sodium Dimethyldithiocarbamate as Thiocarbonyl Surrogate

A simple, expeditious and high-efficiency synthetic method for the AlCl3-mediated one-pot preparation of 2-mercapto benzoheterocycles (2-mercapto benzothiazoles, benzoxazoles and benzimidazoles) is described. By the treatment of a series of S, O and N heteroatoms containing bifunctional molecules with sodium dimethyldithiocarbamate in AlCl3, the desired benzoheterocycles are obtained smoothly. The protocol can also be applied on the synthesis of a series of thiazolidine-2-thiones, imidazolidine-2-thiones. This novel synthetic approach has advantages such as ligand-free, high efficiency, short reaction time, readily available starting materials and simple experimental procedures.

An environmentally benign and efficient synthesis of substituted benzothiazole-2-thiols, benzoxazole-2-thiols, and benzimidazoline-2-thiones in water

An efficient and practical method for the one-step synthesis of benzothiazole-2-thiols, benzoxazole-2-thiols and benzimidazoline-2-thiones by cyclization of 2-aminothiophenols, 2-aminophenols, and 1,2-phenylenediamines with tetramethylthiuram disulfide (TMTD) in water was described. The features of this method include metal/ligand-free, excellent yield, short reaction time and broad substrate scope. The method provides a facile and convenient preparation of some potentially biologically active compounds.