27243-91-0

Basic information

• Product Name: 1-(p-methylphenyl)-1-cyanoacetone
• Synonyms: 1-(p-methylphenyl)-1-cyanoacetone
• CAS NO: 27243-91-0
• Molecular Weight: 173.214
• Mol File: 27243-91-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(p-methylphenyl)-1-cyanoacetone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(p-methylphenyl)-1-cyanoacetone(27243-91-0)
• EPA Substance Registry System: 1-(p-methylphenyl)-1-cyanoacetone(27243-91-0)

Safety Data

• Hazardous Substances Data: 27243-91-0(Hazardous Substances Data)

Usage

Chemical Category

Ketones

Molecular Weight

161.2 g/mol

Physical State

Colorless to light yellow liquid at room temperature

Solubility

Soluble in organic solvents

Applications

Intermediate in the synthesis of various pharmaceuticals and organic compounds

Chemical Reactions

a. Addition of nucleophiles to the cyano group
b. Reduction of the carbonyl group to form corresponding alcohols

Safety Precautions

Hazardous if not properly managed; caution should be taken when handling and storing

Upstream product

• 2947-61-7 (4-methylphenyl)acetonitrile 
• 141-78-6 ethyl acetate 

Downstream Products

• 1159187-59-3 3-methyl-4-(4-methylphenyl)-1H-pyrazol-5-amine 
• 1415678-33-9 C₂₂H₂₃N₅ 
• 1415678-66-8 C₁₈H₁₉N₃O 
• 1415678-65-7 C₁₆H₁₇N₃O 
• 1415678-64-6 C₁₅H₁₂F₃N₃O 
• 1415678-63-5 C₂₀H₁₇N₃O 
• 1415678-62-4 C₁₇H₁₉N₃O 
• 1415678-61-3 C₁₆H₁₇N₃O 
• 1415678-60-2 C₁₅H₁₅N₃O 
• 1415678-32-8 C₁₉H₂₂F₃N₅ 
• 1415678-31-7 C₂₄H₂₇N₅ 
• 1415678-56-6 C₁₈H₁₈ClN₃ 
• 1415678-55-5 C₁₆H₁₆ClN₃ 
• 1415678-54-4 C₁₅H₁₁ClF₃N₃ 

Relevant articles and documents

Stereoselective C?C Oxidative Coupling Reactions Photocatalyzed by Zwitterionic Ligand Capped CsPbBr3 Perovskite Quantum Dots

Semiconductor quantum dots (QDs) have attracted tremendous attention in the field of photocatalysis, owing to their superior optoelectronic properties for photocatalytic reactions, including high absorption coefficients and long photogenerated carrier lifetimes. Herein, by choosing 2-(3,4-dimethoxyphenyl)-3-oxobutanenitrile as a model substrate, we demonstrate that the stereoselective (>99 %) C?C oxidative coupling reaction can be realized with a high product yield (99 %) using zwitterionic ligand capped CsPbBr3 perovskite QDs under visible light illumination. The reaction can be generalized to different starting materials with various substituents on the phenyl ring and varied functional moieties, producing stereoselective dl-isomers. A radical mediated reaction pathway has been proposed. Our study provides a new way of stereoselective C?C oxidative coupling via a photocatalytic means using specially designed perovskite QDs.

Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitor

We describe a novel 7-aminopyrazolo[1,5-a]pyrimidine (7-APP) derivative as a potent hepatitis C virus (HCV) inhibitor. A series of 7-APPs was synthesized and evaluated for inhibitory activity against HCV in different cell culture systems. The synthesis and preliminary structure-activity relationship study of 7-APP are reported.