27258-04-4

Basic information

• Product Name: 1H-Pyrazole,1,1'-methylenebis-
• Synonyms: Pyrazole,1,1'-methylenedi- (8CI); 1,1'-Dipyrazolylmethane; 1,1'-Methylenebis[pyrazole];1,1'-Methylenedipyrazole; Bis(1-pyrazolyl)methane; Bis(1H-pyrazol-1-yl)methane;Bpzm; Di(pyrazol-1-yl)methane
• CAS NO: 27258-04-4
• Molecular Formula: C7H8 N4
• Molecular Weight: 148.167
• Mol File: 27258-04-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 291.2°Cat760mmHg
• Flash Point: 129.9°C
• Density: 1.24g/cm³
• CAS DataBase Reference: 1H-Pyrazole,1,1'-methylenebis-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole,1,1'-methylenebis-(27258-04-4)
• EPA Substance Registry System: 1H-Pyrazole,1,1'-methylenebis-(27258-04-4)

Safety Data

• Hazardous Substances Data: 27258-04-4(Hazardous Substances Data)

Usage

Structure

Symmetric bis-pyrazole compound

Usage

Building block in the synthesis of pharmaceuticals and agrochemicals

Biological Activities

Antifungal, antibacterial, and antitumor properties

Ligand Properties

Bi-dentate ligand, forms coordination complexes with metal ions

Importance

Intermediate in the production of organic compounds

Applications

Medicinal chemistry, materials science

Upstream product

• 80510-03-8 Tris(pyrazolyl)methane 
• 288-32-4 1H-imidazole 
• 75-09-2 dichloromethane 
• 288-13-1 NH-pyrazole 

Downstream Products

• 166662-56-2 [(P(C₆H₅)3)Cu(C₇H₈N₄)Br] 
• 659723-46-3 (5-diphenylphosphanylpyrazol-1-yl)(diphenylphosphanyl)(pyrazol-1-yl)methane disulfide 
• 220526-41-0 bis[5-(diphenylphosphanyl)pyrazol-1-yl]methane 
• 289-95-2 PYRIMIDINE 
• 288-13-1 NH-pyrazole 
• 930-36-9 1-methyl-1H-pyrazole 
• 80510-03-8 Tris(pyrazolyl)methane 
• 26429-26-5 1,2-dimethyl-1H-pyrazol-2-ium iodide 
• 89407-13-6 Bis-(2-pyrazol-1-ylmethyl-2H-pyrazol-3-yl)-p-tolyl-methanol 
• 89407-16-9 2,2-Di-pyrazol-1-yl-1-p-tolyl-ethanone 
• 89407-12-5 Diphenyl-(2-pyrazol-1-ylmethyl-2H-pyrazol-3-yl)-methanol 
• 89407-17-0 1,1-Diphenyl-2,2-di-pyrazol-1-yl-ethanol 
• 89407-18-1 1-Phenyl-2,2-di-pyrazol-1-yl-vinylamine 
• 89407-14-7 1-phenyl-1,1-bis(1'(pyrazol-1-yl-metylene)pyrazole-5'-)methanol 

Relevant articles and documents

N-Polyazolylmethanes. 1. Synthesis and NMR Study of N,N'-Diazolylmethanes

Thirteen N,N'-diazolylmethanes, including derivatives of pyrazole, imidazole, 1,2,4-triazole, benzimidazole and indazole were prepared by reaction of azoles with methylene chloride under phase transfer catalysis conditions.The relative amounts of isomeric mixtures obtained with 'asymmetric' azoles or with equimolar mixtures of azoles are compared with literature results on monoalkylation of azoles.Proton and carbon-13 nmr spectra of the N,N'-diazolylmethanes are discussed.