272786-64-8 Usage
Description
Unifiram (DM-232) is a potent AMPAkine-like nootropic compound, structurally similar to Sunifiram, with effective cognition-enhancing and anti-amnesiac properties in animal models. Despite its structural similarities to racetam compounds, Unifiram is not technically a racetam due to the broken pyrrolidone backbone. It has been shown to have a significantly greater nootropic potency than Piracetam or Phenylpiracetam, with its primary mode of action being through interactions with the glutamatergic system and AMPA-receptor activation.
Uses
Used in Pharmaceutical Industry:
Unifiram is used as a cognition-enhancing agent for improving cognitive performance and memory retention in individuals with cognitive impairments or those seeking to enhance their cognitive abilities. Its anti-amnesiac effects make it a promising candidate for the treatment of memory-related disorders.
Used in Research and Development:
Unifiram is used as a research compound for studying the effects of AMPA-receptor activation on cognitive performance and memory. Its high potency and structural differences from traditional racetams make it an interesting subject for further investigation into the development of novel nootropics and potential therapeutic applications.
Used in Animal Models:
Unifiram is used as a test compound in animal studies to evaluate its effects on cognitive performance and memory retention. These studies provide valuable insights into the potential benefits and mechanisms of action of Unifiram, contributing to the understanding of its therapeutic potential in humans.
benefits
Unifiram is believed to improve learning, memory, concentration, mental energy and basic cognition.
Mode of action
Although the Unifiram did not show any affinity for several important binding sites, it was found to prevent amnesia through modulation of various neurotransmitter systems and by increasing acetylcholine release in the cerebral cortex.Unifiram's mechanism of action is known to be similar to that of Sunifiram. Sunifiram's mechanism of action is better defined than that of Unifiram, and we will briefly explain it here.At a dosage range of 10-100nM, Sunifiram enhances NMDA-dependent signaling by increasing PKCα phosphorylation – dependent on glycine binding site availability and as an antagonist to glycine. The observable increase in AMPA receptor activation activity post-administration has been associated with increases in CAMKII and PKCα phosphorylation. Furthermore, the increased activity of AMPA receptor activation has been associated with increased CAMKII and PKCα phosphorylation.
Check Digit Verification of cas no
The CAS Registry Mumber 272786-64-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,7,2,7,8 and 6 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 272786-64:
(8*2)+(7*7)+(6*2)+(5*7)+(4*8)+(3*6)+(2*6)+(1*4)=178
178 % 10 = 8
So 272786-64-8 is a valid CAS Registry Number.
272786-64-8Relevant articles and documents
Design, synthesis, and preliminary pharmacological evaluation of 1,4- diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic agents
Manetti, Dina,Ghelardini, Carla,Bartolini, Alessandro,Bellucci, Cristina,Dei, Silvia,Galeotti, Nicoletta,Gualtieri, Fulvio,Romanelli, Maria Novella,Scapecchi, Serena,Teodori, Elisabetta
, p. 1969 - 1974 (2007/10/03)
Several 4-substituted 1,4-diazabicyclo[4.3.0]nonan-9-ones have been synthesized and tested in vivo on mouse passive avoidance test, to evaluate their nootropic activity. The results show that they represent a new class of nootropic drugs with a pharmacolo
