273-05-2 Usage
Description
1H-1,2,3-TRIAZOLO[4,5-C]PYRIDINE is a chemical compound characterized by its unique triazolopyridine structure. It is known for its versatile reactivity and potential applications in various fields due to its distinct chemical properties.
Uses
Used in Pharmaceutical Industry:
1H-1,2,3-TRIAZOLO[4,5-C]PYRIDINE is used as an N-acylating and N-alkoxycarbonylation reagent for the synthesis of various pharmaceutical compounds. Its ability to participate in these reactions makes it a valuable tool in the development of new drugs and therapeutic agents.
Used in P2X7 Modulation Therapy:
1H-1,2,3-TRIAZOLO[4,5-C]PYRIDINE is used as a P2X7 modulator, which plays a crucial role in the therapy of various conditions. P2X7 receptors are involved in several physiological processes, and modulation of these receptors can have therapeutic benefits in treating certain diseases.
Used in Lipase Inhibition:
1H-1,2,3-TRIAZOLO[4,5-C]PYRIDINE is used as an inhibitor of hormone-sensitive lipase (HSL) and endothelial lipase (EL). By inhibiting these lipases, it can potentially help in the management of lipid metabolism and related disorders, such as obesity and cardiovascular diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 273-05-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 2,7 and 3 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 273-05:
(5*2)+(4*7)+(3*3)+(2*0)+(1*5)=52
52 % 10 = 2
So 273-05-2 is a valid CAS Registry Number.
InChI:InChI=1/C5H4N4/c1-2-6-3-5-4(1)7-9-8-5/h1-3H,(H,7,8,9)
273-05-2Relevant articles and documents
N-acyl and N-alkoxycarbonyl derivatives of 1H-1,2,3-triazolo-[4,5-c] pyridine; preparation and application
Holt, Jarle,Fiksdahl, Anne
, p. 417 - 423 (2007/10/03)
The N-acylating and N-alkoxycarbonylation ability of the N-substituted 1,2,3-triazolo[4,5-c]pyridines 1a-e have been investigated. The alkoxycarbonyl triazolopyridine derivatives (1c-e) were readily prepared in 81-96% yield (the corresponding tetrafluoroborate > 95%). Triazolo[4,5-c]pyridine (1) has been shown to work as a good leaving group by the formation of amido- and carbamate protected derivatives of primary amines. The method was also successful for the N-tert-butoxycarbonyl (N-BOC) protection of the amino acid, phenylalanine. The synthetic transformations are facilitated by the one-pot preparation of 1a-e followed by the direct reaction with the amines or amino acid. The present method thus offers an efficient and convenient protocol for the in situ preparation of triazolopyridine reagents to be used directly for the protection of amines and amino acids. N-Acyl- and N-alkoxycarbonyl triazolopyridines (1a-e) were readily prepared in 4 steps from 4-aminopyridine (4) by amine protection, pyridine nitration, nitro reduction and diazotizations/cyclizations. All reactions offer the advantages of rapid conversions in high yields under very mild conditions.
