27371-06-8

Basic information

• Product Name: 1-(benzyloxy)-2-methyl-1,2-dihydropyridine
• CAS NO: 27371-06-8
• Molecular Formula: Br*C₁₃H₁₄NO
• Molecular Weight: 201.2643
• Mol File: 27371-06-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 298.9°C at 760 mmHg
• Flash Point: 88.1°C
• Density: 1.07g/cm³
• Vapor Pressure: 0.00123mmHg at 25°C
• Refractive Index: 1.585
• CAS DataBase Reference: 1-(benzyloxy)-2-methyl-1,2-dihydropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(benzyloxy)-2-methyl-1,2-dihydropyridine(27371-06-8)
• EPA Substance Registry System: 1-(benzyloxy)-2-methyl-1,2-dihydropyridine(27371-06-8)

Safety Data

• Hazardous Substances Data: 27371-06-8(Hazardous Substances Data)

Usage

Chemical class

Dihydropyridine derivative

Structural features

Contains a benzyl group (C6H5CH2-)
Contains a methyl group (CH3-)

Potential applications

Pharmaceutical research
Development of new drugs for cardiovascular diseases and hypertension

Use in organic synthesis

Building block for creating other biologically active compounds

Importance in medicinal chemistry

Valuable target for further study and development due to its specific properties and potential uses

Upstream product

• 931-19-1 2-methylpyridine N-oxide 
• 100-39-0 benzyl bromide 

Downstream Products

• 109-06-8 α-picoline 
• 100-52-7 benzaldehyde 

Relevant articles and documents

Collisionally Activated Dissociation of 1-Benzyloxypyridinium Cations.

Eighteen pyridine-ring substituted N-benzyloxypyridinium cations all dissociate by two alternative pathways to give (A) a cation C7H7+ and the substituted pyridine 1-oxide, and (B) a cation C7H7O+ and the substituted pyridine.Appearance potentials (Eapp) have been measured for both pathways; they are higher by 3-17 kcal mol-1 for the dominant pathway (A) than for (B).The Eapp values are compared with the ΔHf values calculated by the AM1 method for reactants and products demonstrating extensive rearrangement in a product-like transition state (TS) for pathway (A) but not for (B).Both sets of Eapp correlate roughly with Σ? for the pyridine ring substituents.For the 4-dimethylamino derivatives, two additional homolytic pathways are found to give (C) a cation Me2NC5H4NO+* and (D) the 4-dimethylaminopyridine radical cation.