273734-07-9 Usage
Enzyme inhibitor
This synthetic CB1 receptor agonist and anandamide (N-
arachidonylethanolamide) analogue (FW = 365.99 g/mol; CAS 220556-69-
4; Symbol: ACEA) is a selective agonist of cannabinoid receptor-1 (Ki =
1.4 nM) but has low affinity to the cannabinoid receptor 2 (Ki = 3.1 μM).
ACEA inhibits forskolin-induced cAMP accumulation in Chinese hamster
ovary cells expressing the human CB1 receptor. It also increases the
binding of [35S]GTPgS to cerebellar membranes and inhibits electrically
evoked contractions of the mouse vas deferens. ACEA produces
hypothermia in mice, an effect that is inhibited by co-administration of the
CB1 receptor antagonist SR141716A.
Check Digit Verification of cas no
The CAS Registry Mumber 273734-07-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,7,3,7,3 and 4 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 273734-07:
(8*2)+(7*7)+(6*3)+(5*7)+(4*3)+(3*4)+(2*0)+(1*7)=149
149 % 10 = 9
So 273734-07-9 is a valid CAS Registry Number.
273734-07-9Relevant articles and documents
Synthesis, cannabinoid receptor activity, and enzymatic stability of reversed amide derivatives of arachidonoyl ethanolamide
Parkkari, Teija,Savinainen, Juha R.,Raitio, Katri H.,Saario, Susanna M.,Matilainen, Laura,Sirvioe, Tuomas,Laitinen, Jarmo T.,Nevalainen, Tapio,Niemi, Riku,Jaervinen, Tomi
, p. 5252 - 5258 (2006)
Retroanandamide (2f) and its 10 analogues (1a-e, 2a-e) were synthesized and evaluated for the cannabinoid receptor activation by a [35S]GTPγS binding assay using rat cerebellar membranes, and Chinese hamster ovary cell membranes expressing huma
