2746-41-0

Basic information

• Product Name: 3-(2-Chlorophenyl)-[1,2,4]triazolo[4,3-a]pyridine
• Synonyms: 3-(2-Chlorophenyl)-[1,2,4]triazolo[4,3-a]pyridine
• CAS NO: 2746-41-0
• Molecular Formula: C₁₂H₈ClN₃
• Molecular Weight: 229.66502
• Mol File: 2746-41-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 132 °C
• Appearance: /
• Density: 1.35±0.1 g/cm3(Predicted)
• PKA: 2.08±0.50(Predicted)
• CAS DataBase Reference: 3-(2-Chlorophenyl)-[1,2,4]triazolo[4,3-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-Chlorophenyl)-[1,2,4]triazolo[4,3-a]pyridine(2746-41-0)
• EPA Substance Registry System: 3-(2-Chlorophenyl)-[1,2,4]triazolo[4,3-a]pyridine(2746-41-0)

Safety Data

• Hazardous Substances Data: 2746-41-0(Hazardous Substances Data)

Upstream product

• 2746-61-4 2-(2-(2-chlorobenzylidene)hydrazinyl)pyridine 
• 109-09-1 2-chloropyridine 
• 4930-98-7 pyrid-2-ylhydrazine 
• 615-41-8 2-iodochlorobenzene 
• 13939-06-5 molybdenum hexacarbonyl 
• 89-98-5 2-chloro-benzaldehyde 
• 2039-87-4 2-chlorostyrene 

Relevant articles and documents

TBAI/TBHP-Catalyzed Synthesis of [1,2,4]Triazolo[4,3-a]pyridines and 3,5-Diaryl-1,2,4-oxadiazoles via Oxidative Cleavage of C=C Double Bond

Abstract: A simple and efficient protocol has been described for the synthesis of [1,2,4]triazolo[4,3-a]pyri-dines and 3,5-disubstituted-1,2,4-oxadiazoles by reacting 2-hydrazinylpyridine and benzamidoximes, respec-tively, with styrenes via TBAI/TBHP-mediated oxidative cleavage of C=C bond under ligand- and metal-free conditions.

Synthesis of 1,2,4-Triazolo[4,3-a]pyridines and Related Heterocycles by Sequential Condensation and Iodine-Mediated Oxidative Cyclization

A facile and efficient approach to access 1,2,4-triazolo[4,3-a]pyridines and related heterocycles has been accomplished through condensation of readily available aryl hydrazines with corresponding aldehydes followed by iodine-mediated oxidative cyclizatio

Efficient synthesis of 3-substituted 1,2,4-triazolo[4,3-a]pyridine by [bis(trifluroacetoxy)iodo]benzene-catalyzed oxidative intramolecular cyclization of heterocyclic hydrazones

A series of 1,2,4-triazolopyridines have been prepared by oxidative intramolecular cyclization of heterocyclic hydrazones with [bis(trifluroacetoxy) iodo]benzene. General applicability of this simple transformation was confirmed by synthesis of 1,2,4-triazolo[4,3-a]pyridine. The advantages of this protocol are the nontoxicity of catalyst and shorter reaction time to obtain good preparative yield.