2746-42-1

Basic information

• Product Name: 1,2,4-Triazolo[4,3-a]pyridine, 3-(4-chlorophenyl)-
• Synonyms: 3-<4-Chlor-phenyl>-s-triazolo<4,3-a>pyridin;Pyrido<2,1-c>-3-<4-chlor-phenyl>-s-triazol;3-(4-chloro-phenyl)-[1,2,4]triazolo[4,3-a]pyridine;3-(4-chlorophenyl)[1,2,4]triazolo[4,3-a]pyridine;3-(4-chlorophenyl)-1,2,4-triazolo[4,3-a]pyridine
• CAS NO: 2746-42-1
• Molecular Formula: C12H8ClN3
• Molecular Weight: 229.669
• Mol File: 2746-42-1.mol
• Article Data: 20

Chemical Properties

• Melting Point: 196 - 199 °C
• CAS DataBase Reference: 1,2,4-Triazolo[4,3-a]pyridine, 3-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Triazolo[4,3-a]pyridine, 3-(4-chlorophenyl)-(2746-42-1)
• EPA Substance Registry System: 1,2,4-Triazolo[4,3-a]pyridine, 3-(4-chlorophenyl)-(2746-42-1)

Safety Data

• Hazardous Substances Data: 2746-42-1(Hazardous Substances Data)

Usage

General Description

1,2,4-Triazolo[4,3-a]pyridine, 3-(4-chlorophenyl)-, also known as TAPTP, is a chemical compound that belongs to the group of triazolopyridines. It is a heterocyclic compound with a fused triazole and pyridine ring structure, and it contains a 4-chlorophenyl group. TAPTP has been studied for its potential applications in the pharmaceutical industry, particularly for its antimicrobial and antifungal properties. It has also been investigated for its potential use as a building block in organic synthesis, due to its unique structure and reactivity. TAPTP is a versatile compound with promising potential for various applications in the field of chemistry and pharmaceuticals.

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Relevant articles and documents

TBAI/TBHP-Catalyzed Synthesis of [1,2,4]Triazolo[4,3-a]pyridines and 3,5-Diaryl-1,2,4-oxadiazoles via Oxidative Cleavage of C=C Double Bond

Abstract: A simple and efficient protocol has been described for the synthesis of [1,2,4]triazolo[4,3-a]pyri-dines and 3,5-disubstituted-1,2,4-oxadiazoles by reacting 2-hydrazinylpyridine and benzamidoximes, respec-tively, with styrenes via TBAI/TBHP-mediated oxidative cleavage of C=C bond under ligand- and metal-free conditions.

A convenient one-pot synthesis of N-fused 1,2,4-triazoles via oxidative cyclization using chromium (VI) oxide

A facile one-pot synthesis of N-fused 1,2,4-triazoles from heterocyclic hydrazines and aldehydes is reported. The reaction is efficiently promoted by chromium (VI) oxide to afford the desired products mostly in high yields and in relatively short time. The high yield of the products and short reaction time are notable advantages of the developed protocol. This protocol is effective toward various substrates having different functionalities.

KI-catalyzed oxidative cyclization of α-keto acids and 2-hydrazinopyridines: Efficient one-pot synthesis of 1,2,4-triazolo[4,3-a] pyridines

A one-pot approach to substituted 1,2,4-triazolo[4,3-a]pyridines has been developed that is based on a KI-catalyzed oxidative cyclization of α-keto acids and 2-hydrazinopyridines. This transition-metal-free procedure was highly efficient and shows good economical and environmental advantages.