2746-47-6

Basic information

• Product Name: 1,2,4-Triazolo[4,3-a]pyridine, 3-(4-methylphenyl)-
• CAS NO: 2746-47-6
• Molecular Formula: C13H11N3
• Molecular Weight: 209.25
• Mol File: 2746-47-6.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 1,2,4-Triazolo[4,3-a]pyridine, 3-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Triazolo[4,3-a]pyridine, 3-(4-methylphenyl)-(2746-47-6)
• EPA Substance Registry System: 1,2,4-Triazolo[4,3-a]pyridine, 3-(4-methylphenyl)-(2746-47-6)

Safety Data

• Hazardous Substances Data: 2746-47-6(Hazardous Substances Data)

Usage

Type of Compound

Heterocyclic compound

Structure

Contains a triazolopyridine ring and a 3-(4-methylphenyl) substituent

Pharmaceutical drugs

Studied for its potential biological activities

Materials science

Investigated for its potential use in the field

Versatility

Range of potential applications in various fields

Upstream product

• 109-09-1 2-chloropyridine 
• 4930-98-7 pyrid-2-ylhydrazine 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 110-86-1 pyridine 
• 104-87-0 4-methyl-benzaldehyde 
• 7163-50-0 (4-methylphenyl)(oxo)acetic acid 
• 5977-87-7 4-methyl-dithiobenzoic acid methyl ester 
• 624-31-7 4-tolyl iodide 
• 13939-06-5 molybdenum hexacarbonyl 
• 274-80-6 [1,2,4]triazolo[4,3-a]pyridine 
• 2824-70-6 2-(2-(4-mehtylbenzylidene)hydrazinyl)pyridine 

Relevant articles and documents

TBAI/TBHP-Catalyzed Synthesis of [1,2,4]Triazolo[4,3-a]pyridines and 3,5-Diaryl-1,2,4-oxadiazoles via Oxidative Cleavage of C=C Double Bond

Abstract: A simple and efficient protocol has been described for the synthesis of [1,2,4]triazolo[4,3-a]pyri-dines and 3,5-disubstituted-1,2,4-oxadiazoles by reacting 2-hydrazinylpyridine and benzamidoximes, respec-tively, with styrenes via TBAI/TBHP-mediated oxidative cleavage of C=C bond under ligand- and metal-free conditions.

Facile one pot synthesis of N-fused 1,2,4-triazoles via oxidative cyclisation using DDQ

A facile and expedient one pot synthesis of N-fused 1,2,4-triazoles from 2-hydrazinopyridines or 2-hydrazinopyrazines and aldehydes is described via oxidative cyclization using DDQ as a safe and convenient oxidizing agent and polyethylene glycol as recyclable reaction medium. This protocol is effective toward various substrates having different functionalities. The easy recyclability of the reaction medium makes the process economic and potentially viable for commercial applications.

KI-catalyzed oxidative cyclization of α-keto acids and 2-hydrazinopyridines: Efficient one-pot synthesis of 1,2,4-triazolo[4,3-a] pyridines

A one-pot approach to substituted 1,2,4-triazolo[4,3-a]pyridines has been developed that is based on a KI-catalyzed oxidative cyclization of α-keto acids and 2-hydrazinopyridines. This transition-metal-free procedure was highly efficient and shows good economical and environmental advantages.