2753-45-9 Usage
Description
Mebeverine hydrochloride is a white solid that belongs to the class of muscarinic agonists. It is primarily used for its antispasmodic and smooth muscle relaxant properties, making it a valuable compound in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
Mebeverine hydrochloride is used as a muscarinic ACh agonist for its antispasmodic and smooth muscle relaxant effects. It is particularly effective in treating conditions that involve smooth muscle spasms, such as irritable bowel syndrome (IBS) and other gastrointestinal disorders.
Used in Ophthalmology:
In the field of ophthalmology, Mebeverine hydrochloride is used as an antiglaucoma agent. Its smooth muscle relaxant properties help to reduce intraocular pressure, which is a common issue in glaucoma patients. By alleviating this pressure, Mebeverine hydrochloride can help prevent further damage to the optic nerve and slow down the progression of the disease.
Used in Gastroenterology:
Mebeverine hydrochloride is also used in gastroenterology as a smooth muscle relaxant and antispasmodic. It is particularly useful in treating conditions like irritable bowel syndrome (IBS), where it can help to alleviate symptoms such as abdominal pain, bloating, and diarrhea by reducing the frequency and intensity of muscle contractions in the gastrointestinal tract.
Originator
Duspatalin,Duphar,France,1965
Manufacturing Process
(A) Sodium-3,4-Dimethoxybenzoate: A solution of 91 g of 3,4- dimethoxybenzoic acid in 500 ml of boiling, absolute alcohol was added quickly to a solution of 11.5 g of sodium in 300 ml of absolute alcohol; after cooling to room temperature the resulting precipitate was filtered off and washed with 2 x 50 ml of absolute alcohol and 4 x 200 ml of ether and dried in air to constant weight; yield 92.5 g, MP about 265°C. The filtrate was bulked with the alcohol and ether washings, left to stand overnight, and a further precipitate then filtered off, washed with 3 x 100 ml of ether, and dried in air to constant weight. Yield 22.5 g, MP about 265°C. Total yield therefore 115 g (=113%).(B) 4'-Chlorobutyl-3,4-Dimethoxybenzoate: 92 g of the sodium salt described
under (A) (it contains at the most 81.5 g of sodium 3,4-dimethoxybenzoate)
was boiled in 900 ml of tetramethylene dichloride for 90 hours; after cooling
the mixture was filtered and the residue washed with 3 x 50 ml of ether. The
filtrate was evaporated to dryness in vacuo and the residue (102 g) was
distilled in vacuo. Fraction 1: 50° to 55°C/0.5 mm; 19 g (probably
tetramethylene dichloride). Fraction 2: 175° to 184°C/0.5 mm; 77.5 g
(=71%); Cl= 12.6% (calculated 13.0%). Remark: The second fraction
partially solidified or became more viscous on standing, and even during the
distillation.(C) 4'-Iodobutyl-3,4-Dimethoxybenzoate: 32.5 g of 4'-chlorobutyl-3,4-
dimethoxybenzoate and 19.5 g of sodium iodide (10% excess) were boiled in
150 ml of methyl ethyl ketone for 2.5 hours; after cooling and filtering off the
sodium chloride produced, the reaction was found not to be entirely
completed; boiling was then continued for another two hours; the reaction
mixture was cooled, and the solid filtered off and washed with 2 x 100 ml of
ether.The filtrate was evaporated to dryness in vacuo and the residue was dissolved
in 300 ml of ether and 100 ml of water; the layers were separated and the
water layer was once again extracted with 100 ml of ether; then the ether
layers were boiled and washed again with a solution of 3.5 g of sodium
thiosulfate in 100 ml of water. The ether layer was dried over sodium sulfate.
Finally the solution was filtered and the ether was evaporated; the residue
was an almost colorless oil, which partially solidified or became more viscous
after being left to stand for some time. Yield: 40 g (=92%), I=34.2%
(calculated 34.9%).(D) 4'-[N-Ethyl-1''-Methyl-2''-(4'''-Methoxyphenyl)Ethylamino]Butyl-3,4-
Dimethoxybenzoate Hydrochloride: 10.3 g of 4'-iodobutyl-3,4-
dimethoxybenzoate and 11.0 g of N-ethyl-p-methoxyphenylisopropylamine
(obtained by catalytic reduction of an alcoholic solution of an excess quantity
(60%) of p-methoxy-phenyl-acetone, to which was added a 33% (weight-for-weight) aqueous solution of ethylamine, with Pt as a catalyst), were boiled in
200 ml of methyl ethyl ketone for 20 hours, cooled and the iodine ion was
determined; the reaction was found to be complete. Then the methyl ethyl
ketone was evaporated in vacuo and the residue was dissolved in 300 ml of
water and 30 ml of ether; the layers were separated and the water layer was
extracted twice more with 20 ml portions of ether.
Therapeutic Function
Spasmolytic
Check Digit Verification of cas no
The CAS Registry Mumber 2753-45-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,7,5 and 3 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 2753-45:
(6*2)+(5*7)+(4*5)+(3*3)+(2*4)+(1*5)=89
89 % 10 = 9
So 2753-45-9 is a valid CAS Registry Number.
InChI:InChI=1/C25H35NO5.ClH/c1-6-26(19(2)17-20-9-12-22(28-3)13-10-20)15-7-8-16-31-25(27)21-11-14-23(29-4)24(18-21)30-5;/h9-14,18-19H,6-8,15-17H2,1-5H3;1H
