2754-17-8

Basic information

• Product Name: bis(2,3-epoxypropyl) adipate
• Synonyms: bis(2,3-epoxypropyl) adipate;Adipic acid diglycidyl ester;Hexanedioic acid bis[(oxiran-2-yl)methyl] ester
• CAS NO: 2754-17-8
• Molecular Formula: C₁₂H₁₈O₆
• Molecular Weight: 258.26772
• EINECS: 220-403-7
• Mol File: 2754-17-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 371.2 °C at 760 mmHg
• Flash Point: 164.3 °C
• Appearance: /
• Density: 1.24 g/cm³
• Vapor Pressure: 1.05E-05mmHg at 25°C
• Refractive Index: 1.491
• CAS DataBase Reference: bis(2,3-epoxypropyl) adipate(CAS DataBase Reference)
• NIST Chemistry Reference: bis(2,3-epoxypropyl) adipate(2754-17-8)
• EPA Substance Registry System: bis(2,3-epoxypropyl) adipate(2754-17-8)

Safety Data

• Hazardous Substances Data: 2754-17-8(Hazardous Substances Data)

Usage

General Description

Bis(2,3-epoxypropyl) adipate is a chemical compound that is commonly used as a cross-linking agent in the production of epoxy resins. It is a diester of adipic acid and is typically added to epoxy formulations to improve their flexibility and impact resistance. This chemical is also used as a plasticizer in certain applications, such as adhesives, coatings, and sealants. Bis(2,3-epoxypropyl) adipate is considered to have low toxicity and is not known to cause significant health hazards when used in accordance with proper handling and safety guidelines. However, it is still important to exercise caution and follow all safety recommendations when working with this chemical.

InChI:InChI=1/C12H18O6/c13-11(17-7-9-5-15-9)3-1-2-4-12(14)18-8-10-6-16-10/h9-10H,1-8H2

Upstream product

• 2998-04-1 diallyl adipate 

Relevant articles and documents

Biodegradable cross-linked poly(amino alcohol esters) based on LMW PEI for gene delivery

Polyethylenimine (PEI, especially with Mw of 25000) has been known as an efficient gene carrier and a gold standard of gene transfection due to its high transfection efficiency (TE). However, high concomitant cytotoxicity limited the application of PEI. In this report, several cationic polymers derived from low molecular weight (LMW) PEI (Mw 600) linked with diglycidyl adipate (DA-PEI) or its analogs (diglycidyl succinate, DS-PEI and diglycidyl oxalate, DO-PEI; D-PEIs for all 3 polymers) were prepared and characterized. GPC gave Mws of DA-PEI, DS-PEI and DO-PEI as 6861, 16015 and 35281, respectively. Moreover, degradation of the ester-containing DS-PEI was also confirmed by GPC. In addition, hydroxyls in these polymers could improve their water solubility. These polymers exhibited good ability to condense plasmid DNA into nanoparticles with the size of 120-250 nm. ζ-potentials of the polyplexes were found to be around +10-20 mV under weight ratios (polymer/DNA) from 0.5 to 32. Agarose gel retardation showed that DNA could be released from the polyplexes after being pre-incubated for 30 h. In vitro experiments were carried out and it was found that DS-PEI showed about 5 times of TE compared to that of the PEI/DNA polyplex under a weight ratio of 1 in A549 cells. Meanwhile, the cytotoxicity of D-PEIs assayed by MTT is lower than that of 25 kDa PEI in HEK293 cells. These results suggested that this series of PEI derivatives would be promising non-viral biodegradable vectors for gene delivery. The Royal Society of Chemistry.