27545-73-9

Basic information

• Product Name: 2-Propenenitrile, 3-amino-3-(3-chlorophenyl)-
• CAS NO: 27545-73-9
• Molecular Formula: C9H7ClN2
• Molecular Weight: 178.621
• Mol File: 27545-73-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Propenenitrile, 3-amino-3-(3-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenenitrile, 3-amino-3-(3-chlorophenyl)-(27545-73-9)
• EPA Substance Registry System: 2-Propenenitrile, 3-amino-3-(3-chlorophenyl)-(27545-73-9)

Safety Data

• Hazardous Substances Data: 27545-73-9(Hazardous Substances Data)

Upstream product

• 766-84-7 3-chloro-benzonitrile 
• 75-05-8 acetonitrile 
• 1529-41-5 3-chloro-benzeneacetonitrile 

Downstream Products

• 21667-62-9 3-chlorobenzoylacetonitrile 
• 1233219-56-1 3-acetylamino-3-(m-chlorophenyl)acrylonitrile 

Relevant articles and documents

ROCK-INHIBITING COMPOUND AND USES THEREOF

Disclosed herein are a compound of formula (I) and a preparation method and uses thereof. The compound shows a good inhibitory activity against ROCK, providing a new medicinal strategy to clinically treat the diseases associated with abnormal ROCK activity.

Rhodium-catalyzed asymmetric hydrogenation of β-acetylamino acrylonitriles

The rhodium-catalyzed asymmetric hydrogenation of β-acetylamino acrylonitriles was investigated by using monophosphine and bisphosphine ligands. It was found that an Rh-QuinoxP complex exhibited high enantioselectivities for β-aryl substituted β-acetylamino acrylonitriles and the Rh-JosiPhos CyPF-t-Bu complex was proven to be effective for the hydrogenation of tetrasubstituted olefins from cyclic β-acetylamino acrylonitriles.