27546-46-9

Basic information

• Product Name: Benzene, 1-cyclopropyl-2-Methyl-
• Synonyms: Benzene, 1-cyclopropyl-2-Methyl-
• CAS NO: 27546-46-9
• Molecular Formula: C₁₀H₁₂
• Molecular Weight: 132.20228
• Mol File: 27546-46-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 202°Cat760mmHg
• Flash Point: 66.7°C
• Appearance: /
• Density: 0.988g/cm³
• Vapor Pressure: 0.425mmHg at 25°C
• Refractive Index: 1.558
• CAS DataBase Reference: Benzene, 1-cyclopropyl-2-Methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-cyclopropyl-2-Methyl-(27546-46-9)
• EPA Substance Registry System: Benzene, 1-cyclopropyl-2-Methyl-(27546-46-9)

Safety Data

• Hazardous Substances Data: 27546-46-9(Hazardous Substances Data)

Usage

General Description

Benzene, 1-cyclopropyl-2-methyl-, also known as 1-cyclopropyl-2-methylbenzene, is a chemical compound with the molecular formula C10H12. It is a colorless liquid with a sweet odor and is insoluble in water. Benzene, 1-cyclopropyl-2-Methyl- is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also used as a solvent and as a chemical intermediate in the production of dyes, flavors, and fragrances. However, it is important to handle this compound with caution as it is considered harmful if inhaled, causes skin irritation, and may be harmful if swallowed. Additionally, it is classified as a possible human carcinogen by the International Agency for Research on Cancer (IARC).

InChI:InChI=1/C10H12/c1-8-4-2-3-5-10(8)9-6-7-9/h2-5,9H,6-7H2,1H3

Upstream product

• 75-11-6 diiodomethane 
• 611-15-4 1-methyl-2-vinyl-benzene 
• 1607-29-0 bis((1-methylcyclopropyl)formyl)peroxide 
• 108-88-3 toluene 
• 67-66-3 chloroform 
• 95-46-5 2-methylphenyl bromide 
• 23719-80-4 cyclopropylmagnesium bromide 
• 873-49-4 cyclopropylbenzene 
• 74-88-4 methyl iodide 
• 20034-51-9 2-cyclopropylbenzaldehyde 
• 411235-57-9 cyclopropylboronic acid 

Downstream Products

• 71096-12-3 4-Brom-1-cyclopropyl-2-methylbenzol 
• 1587-04-8 1-methyl-2-(2-propenyl)-benzene 
• 7399-49-7 1-methyl-2-(prop-1-en-2-yl)benzene 
• 2077-33-0 1-methyl-2-[(1Z)-prop-1-en-1-yl]benzene 
• 2077-34-1 (E)-1-(o-methylphenyl)-1-propene 
• 71096-19-0 7-(4-Cyclopropyl-3-methyl-phenyl)-cyclohepta-1,3,5-triene 

Relevant articles and documents

The copper-catalyzed ring-opening reactions of cyclopropanes by N-fluorobenzenesulfonimide toward N-allylsulfonamides

In this paper, we reported a copper-catalyzed ring-opening reaction of arylcyclopropanes by N-fluorobenzenesulfonimide, leading to N-allylsulfonamides in moderate to good yields. This procedure tolerated bromo, fluoro, trifluoromethyl, phenyl and alkyl groups in the phenyl, proceeding with a sequential ring-opening of arylcyclopropanes, and copper-mediated β-H elimination of alkyl radical.

Lewis Base-Promoted Ring-Opening 1,3-Dioxygenation of Unactivated Cyclopropanes Using a Hypervalent Iodine Reagent

A facile and effective system has been developed for the regio- and chemoselective ring-opening/electrophilic functionalization of cyclopropanes through C?C bond activation by [bis(trifluoroacetoxy)iodo]benzene with the aid of the Lewis basic promoter p-toluenesulfonamide. The p-toluenesulfonamide-promoted system works well for a wide range of cyclopropanes, resulting in the formation of 1,3-diol products in good yields and regioselectivity.

Preparation and Ring-Opening of Benzylic and Allylic Cyclopropyl Dianions

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