27559-45-1

Basic information

• Product Name: M-HYDROXYBENZANILIDE
• Synonyms: 3-HYDROXYBENZANILIDE;M-HYDROXYBENZANILIDE;BenzaMide, 3-hydroxy-N-phenyl-
• CAS NO: 27559-45-1
• Molecular Formula: C₁₃H₁₁NO₂
• Molecular Weight: 213.23
• Mol File: 27559-45-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 153°C
• Boiling Point: 315.9°Cat760mmHg
• Flash Point: 144.8°C
• Appearance: /
• Density: 1.278g/cm³
• PKA: 9.27±0.10(Predicted)
• CAS DataBase Reference: M-HYDROXYBENZANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: M-HYDROXYBENZANILIDE(27559-45-1)
• EPA Substance Registry System: M-HYDROXYBENZANILIDE(27559-45-1)

Safety Data

• Statements: 36/37/38-52
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 27559-45-1(Hazardous Substances Data)

Upstream product

• 99-06-9 3-Carboxyphenol 
• 62-53-3 aniline 
• 142-04-1 aniline hydrochloride 
• 586-38-9 3-Methoxybenzoic acid 
• 33577-82-1 3-acetoxy-benzoic acid anilide 
• 591-50-4 iodobenzene 
• 22241-18-5 3-hydroxybenzaldehyde oxime 
• 5368-81-0 methyl 3-methoxybenzoate 
• 6833-23-4 3-methoxy-N-phenylbenzamide 
• 100-83-4 meta-hydroxybenzaldehyde 

Downstream Products

• 222978-32-7 3-(2-cyano-5-imidazol-1-ylmethyl-phenoxy)-N-phenyl-benzamide 
• 548765-87-3 methyl-phenyl-carbamic acid 3-phenylcarbamoyl-phenyl ester 
• 93189-07-2 N-(3-hydroxybenzyl)benzenamine 

Relevant articles and documents

Metal-Free Sustainable Synthesis of Amides via Oxidative Amidation Using Graphene Oxide as Carbocatalyst in Aqueous Medium

Abstract: We describe an efficient, clean and metal-free procedure for the synthesis of amides via oxidative amidation of aldehydes with anilines using graphene oxide (GO) as a recyclable catalyst and KBrO3 as a mild oxidant in aqueous medium under microwave irradiation. GO nanosheets were prepared and characterized by XRD, TEM, SEM, and FT-IR, analyses. GO showed high compatibility with KBrO3 in water and offered high TOF value (1.30 × 10?3 mol?g?1 min?1). GO oxygen functionalities catalyze the oxidative amidation effectively in mild condition with high recyclability. A plausible mechanism was proposed by the isolating the intermediate. Graphic Abstract: [Figure not available: see fulltext. ]

Cobalt(III)-Catalyzed Construction of Benzofurans, Benzofuranones and One-Pot Orthogonal C?H Functionalizations to Access Polysubstituted Benzofurans

Benzofuran and benzofuranone derivatives have been synthesized through exclusive 5-exo-dig intramolecular hydroarylation using the amide-directed, cost-effective, high-valent Cp*CoIII-catalytic system. Challenging one-pot, orthogonal C?H functionalizations using two different electrophiles are also reported to afford polysubstituted benzofurans. Several valuable functional group interconversions along with removal of the amide directing group provide a route to access several diversely functionalized benzofurans. The mechanistic study suggests a reversible cobaltation step is operative here. (Figure presented.).

Copper-catalyzed regioselective synthesis of N-aryl amides from aldoximes and aryl halides

Ligand-assisted copper-catalyzed reaction of aldoximes with aryl halides is described for the regioselective synthesis of N-aryl amides. This protocol is simple and compatible with a wide range of functional groups attached to the aryl ring of the halides as well as aldoximes. Copyright