2764-03-6

Basic information

• Product Name: glycine linoleamide
• Synonyms: glycine linoleamide;Linoleoyl Glycine;YCRHZEHWEYAHCO-HZJYTTRNSA-N
• CAS NO: 2764-03-6
• Molecular Formula: C20H35 N O3
• Molecular Weight: 337.5
• Mol File: 2764-03-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 0.150 °C (approx)
• Boiling Point: 530.7°Cat760mmHg
• Flash Point: 274.8°C
• Appearance: /Solid
• Density: 0.974g/cm³
• Vapor Pressure: 1.11E-12mmHg at 25°C
• Refractive Index: 1.489
• PKA: 3.59±0.10(Predicted)
• CAS DataBase Reference: glycine linoleamide(CAS DataBase Reference)
• NIST Chemistry Reference: glycine linoleamide(2764-03-6)
• EPA Substance Registry System: glycine linoleamide(2764-03-6)

Safety Data

• RTECS: MC0596320
• Hazardous Substances Data: 2764-03-6(Hazardous Substances Data)

Usage

General Description

Glycine linoleamide is a chemical compound derived from glycine, an amino acid, and linoleic acid, an essential fatty acid. It is often used as an emollient and skin conditioning agent in cosmetic and personal care products. Glycine linoleamide is known for its moisturizing and nourishing properties, as well as its ability to improve the skin's barrier function. Its emollient properties make it effective in softening and smoothing the skin, and it is often used in moisturizers, lotions, and other skincare products. Additionally, glycine linoleamide has been shown to have anti-inflammatory and antioxidant effects, making it a valuable ingredient in skincare formulations aimed at improving skin health and appearance.

InChI:InChI=1/C20H35NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19(22)21-18-20(23)24/h6-7,9-10H,2-5,8,11-18H2,1H3,(H,21,22)(H,23,24)/b7-6-,10-9-

Upstream product

• 60-33-3 linoleic acid 
• 56-40-6 glycine 
• 69888-88-6 N-succinimidyl cis,cis-9,12-octadecadienoate 

Relevant articles and documents

Preparation method and application of compound with beta amyloid protein resisting activity

The present invention provides a compound represented by formula I, or a pharmaceutically acceptable salt thereof. The invention also provides a preparation method of the compound. Experimental results show that the compound is suitable for industrial pro

Evaluation of endogenous fatty acid amides and their synthetic analogues as potential anti-inflammatory leads

A series of endogenous fatty acid amides and their analogues (1-78) were prepared, and their inhibitory effects on pro-inflammatory mediators (NO, IL-1β, IL-6, and TNF-α) in LPS-activated RAW264.7 cells were evaluated. Their inhibitory activity on the pro-inflammatory chemokine MDC in IFN-γ-activated HaCaT cells was also examined. The results showed that the activity is strongly dependent on the nature of the fatty acid part of the molecules. As expected, the amides derived from enone fatty acids showed significant activity and were more active than those derived from other types of fatty acids. A variation of the amine headgroup also altered bioactivity profile remarkably, possibly by modulating cell permeability. Regarding the amine part of the molecules, N-acyl dopamines exhibited the most potent activity (IC50 ～2 μM). This is the first report of the inhibitory activity of endogenous fatty acid amides and their analogues on the production of nitric oxide, cytokines (IL-1β, IL-6, and TNF-α) and the chemokine MDC. This study suggests that the enone fatty acid-derived amides (such as N-acyl ethanolamines and N-acyl amino acids) and N-acyl dopamines may be potential anti-inflammatory leads.