2766-74-7 Usage
Description
5-Chlorothiophene-2-sulfonyl chloride is a sulfonylthiophene derivative characterized by its white to yellow crystalline low melting solid appearance. It can be synthesized from 2-chlorothiophene by reacting with chlorosulfonic acid in the presence of phosphorus pentachloride.
Uses
Used in Pharmaceutical Industry:
5-Chlorothiophene-2-sulfonyl chloride is used as a key intermediate for the preparation of Notch-1-sparing γ-secretase inhibitors, which are crucial in the treatment of Alzheimer's disease. These inhibitors help modulate the Notch signaling pathway, which plays a significant role in the progression of the disease.
Used in Organic Synthesis:
5-Chlorothiophene-2-sulfonyl chloride serves as an important raw material and intermediate in organic synthesis, where it is utilized to create a variety of complex organic compounds.
Used in Agrochemicals Industry:
In the agrochemicals industry, 5-Chlorothiophene-2-sulfonyl chloride is employed as a vital intermediate for the synthesis of various agrochemical products, contributing to the development of effective pest control solutions.
Used in Dyestuffs Industry:
5-Chlorothiophene-2-sulfonyl chloride is also used in the dyestuffs industry as a key component in the production of different types of dyes, enhancing the colorfastness and performance of the final products.
Synthesis Reference(s)
Tetrahedron, 21, p. 1333, 1965 DOI: 10.1016/S0040-4020(01)98293-6
Check Digit Verification of cas no
The CAS Registry Mumber 2766-74-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,7,6 and 6 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 2766-74:
(6*2)+(5*7)+(4*6)+(3*6)+(2*7)+(1*4)=107
107 % 10 = 7
So 2766-74-7 is a valid CAS Registry Number.
InChI:InChI=1/C4H2Cl2O2S2/c5-3-1-2-4(9-3)10(6,7)8/h1-2H
2766-74-7Relevant articles and documents
[4-(6-FLUORO-7-METHYLAMINO-2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL)-PHENYL]-5-CHLORO-THIOPHEN-2-YL-SULFONYLUREA SALTS, FORMS AND METHODS RELATED THERETO
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Page/Page column 61-62, (2009/01/23)
The present invention provides novel sulfonylurea salts of a salt of formula (I) and polymorph forms thereof. The compounds in their various forms are effective platelet ADP receptor inhibitors and may be used in various pharmaceutical compositions, and a
Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives
Mader, Mary M.,Shih, Chuan,Considine, Eileen,De Dios, Alfonso,Grossman, Cora Sue,Hipskind, Philip A.,Lin, Ho-Shen,Lobb, Karen L.,Lopez, Beatriz,Lopez, Jose E.,Cabrejas, Luisa M. Martin,Richett, Michael E.,White, Wesley T.,Cheung, Yiu-Yin,Huang, Zhongping,Reilly, John E.,Dinn, Sean R.
, p. 617 - 620 (2007/10/03)
The anti-proliferative activity of acylated heterocyclic sulfonamides is described in Vascular Endothelial Growth Factor-dependent Human Umbilical Vascular Endothelial Cells (VEGF-HUVEC) and in HCT116 tumor cells in a soft agar diffusion assay.
2,3-Dihydro-3-oxo-thienoisothiazol-1,1-dioxides and their 3-thioxo compounds
Unterhalt,Moghaddam
, p. 115 - 117 (2007/10/02)
2,3-Dihydro-3-oxo-thieno[2,3-d]isothiazole-1,1-dioxide and 2,3-Dihydro-3-oxo-thieno[3,2-d]isothiazole-1,1-dioxide are synthesized. The latter compound can be prepared from 2-chlorothiophene in five steps. Both substances react with Lawessons reagent to give the 3-thioxo derivatives.
