27675-40-7 Usage
Description
Cocculidine is an alkaloid derived from the plant Cocculus pendulus, which has been traditionally used in various medicinal applications. Its crystal structure has been established through X-ray crystallography, providing insights into its molecular structure and potential interactions with other molecules.
Uses
Used in Pharmaceutical Industry:
Cocculidine is used as a pharmaceutical compound for its potential therapeutic effects. It has been found to have various bioactive properties, which can be harnessed for the development of new drugs and treatments.
Used in Traditional Medicine:
Cocculidine has been utilized in traditional medicine for its alleged beneficial properties, such as its ability to treat certain ailments and conditions. Its use in this context is based on historical and cultural practices, and further research may be needed to fully understand its efficacy and safety.
Used in Research and Development:
The crystal structure of cocculidine, as determined through X-ray crystallography, can be used as a basis for further research and development in the field of medicinal chemistry. Understanding its molecular structure can help scientists design new drugs or modify existing ones to improve their effectiveness and safety.
Used in Drug Delivery Systems:
Similar to gallotannin, cocculidine could potentially be incorporated into drug delivery systems to enhance its bioavailability and therapeutic outcomes. By using carriers such as organic or metallic nanoparticles, the delivery, efficacy, and safety of cocculidine could be improved for various applications.
References
Razakov et al., Chern. Cornrnun., 150 (1974)
Check Digit Verification of cas no
The CAS Registry Mumber 27675-40-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,6,7 and 5 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 27675-40:
(7*2)+(6*7)+(5*6)+(4*7)+(3*5)+(2*4)+(1*0)=137
137 % 10 = 7
So 27675-40-7 is a valid CAS Registry Number.
27675-40-7Relevant articles and documents
Elsohly et al.
, p. 132,133 (1976)
Erythrina Alkaloid Analogues as nAChR Antagonists-A Flexible Platform for Leads in Drug Discovery
Clementson, Sebastian,Matheu, Sergio Armentia,R?rsted, Emil M?rcher,Pedersen, Henrik,Jensen, Anders A.,Clausen, Rasmus P.,Vital, Paulo,Glibstrup, Emil,Jessing, Mikkel,Kristensen, Jesper L.
, p. 8248 - 8262 (2021/06/28)
Erythrina alkaloids and their central nervous system effects have been studied for over a century, mainly due to their potent antagonistic actions at β2-containing nicotinic acetylcholine receptors (nAChRs). In the present work, we report a synthetic approach giving access to a diverse set of Erythrina natural product analogues and present the enantioselective total synthesis of (+)-Cocculine and (+)-Cocculidine, both found to be potent antagonists of the β2-containing nAChRs.
ALKALOIDS OF COCCULUS LAURIFOLIUS D.C.
Bhakuni, Dewan S.,Jain, Sudha
, p. 3107 - 3114 (2007/10/02)
Ten new abnormal Erythrina alkaloids, isococculidine, isococculine, coccuvine, coccuvinine, cocculitine, cocculitinine, coccudinone, cocculimine, coccudienone, coccoline and coccolinine have been isolated from the leaves of Cocculus laurifolius D.C. and their structures and stereochemistry is assigned by chemical transformations and spectral studies.The known proaporphine alkaloid stepharine and the morphinandienone alkaloid, sebiferine have also been isolated for the first time from the plant.
