27693-67-0Relevant articles and documents
Photochemical transformation of flufenamic acid by artificial sunlight in aqueous solutions
Rafqah, Salah,Sarakha, Mohamed
, p. 1 - 6 (2016)
In the present article, we have studied the photochemical behavior of a common non-steroidal anti-inflammatory drug (NSAIDs) namely flufenamic acid (FLUA) in aqueous solution. The absorption spectrum of such compound shows a significant absorption beyond
2,7-Dihydro-3H-pyridazino[5,4,3-kl]acridin-3-one derivatives, novel type of cytotoxic agents active on multidrug-resistant cell lines. Synthesis and biological evaluation
Stefanska, Barbara,Bontemps-Gracz, Maria M.,Antonini, Ippolito,Martelli, Sante,Arciemiuk, Malgorzata,Piwkowska, Agnieszka,Rogacka, Dorota,Borowski, Edward
, p. 1969 - 1975 (2007/10/03)
We have earlier postulated that the presence of a pyridazone ring fused with an anthracenedione moiety resulted in the analog's ability to overcome multidrug resistance of tumor cells [J. Med. Chem. 1999, 42, 3494]. High cytotoxic activity of obtained ant
Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase
Lowe III,Archer,Chapin,Cheng,Helweg,Johnson,Koe,Lebel,Moore,Nielsen,Russo,Shirley
, p. 624 - 628 (2007/10/02)
A series of quinazolinediones and azaquinazolinediones is described which possess potent inhibitory activity toward the calcium-independent phosphodiesterase enzyme (CaIPDE). In vivo testing showed that this in vitro activity translates to animal models p