27695-13-2Relevant articles and documents
Synthesis and vasorelaxant and antiplatelet activities of a new series of (4-Benzylphthalazin-1-ylamino)alcohol derivatives
Munín, Javier,Quezada, Elías,Campos-Toimil, Manuel,Cano, Ernesto,Uriarte, Eugenio,Vi?a, Dolores
, p. 1682 - 1688 (2017)
A new series of phthalazine derivatives was synthesized by reaction of phthalic anhydride and different substituted phenylacetic acids to yield the benzyliden-3H-isobenzofuran-1-one intermediates 2a–d. Treatment of them with hydrazine afforded 4-benzyl-2H-phthalazin-1-one derivatives 3a–d, which were substituted with the corresponding aminoalkylalcohol to obtain the (4-benzylphthalazin-1-ylamino)alcohol derivatives 4a–h. In general, these phthalazine derivatives relaxed the contractions produced by phenylephrine both in intact or endothelium-denuded aortic rings. In addition, platelet aggregation induced by thrombin was also inhibited by compounds 4c and 4g.
Pd-free Sonogashira coupling: One pot synthesis of phthalide via domino Sonogashira coupling and 5-exo-dig cyclization
Dhara, Shubhendu,Singha, Raju,Ghosh, Munmun,Ahmed, Atiur,Nuree, Yasin,Das, Anuvab,Ray, Jayanta K.
, p. 42604 - 42607 (2015/02/19)
Phthalides have been synthesized exclusively in one pot via Pd-free Sonogashira coupling. A Cu-catalyzed domino Sonogashira coupling and 5-exo-dig cyclization between suitable substituted ortho-bromobenzoic acids and terminal alkynes afforded phthalides in good yields under mild reaction conditions.
The effect of alkylsubstitution in drugs. V. Synthesis and chemical properties of some dibenzo [a,d]1,4-cycloheptadienyl ethers.
van der STELT,HARMS,NAUTA
, p. 335 - 349 (2007/10/05)
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