27720-05-4

Basic information

• Product Name: L-Phenylalanine, N,N-dimethyl-, methyl ester
• CAS NO: 27720-05-4
• Molecular Formula: C12H17NO2
• Molecular Weight: 207.272
• Mol File: 27720-05-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: L-Phenylalanine, N,N-dimethyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phenylalanine, N,N-dimethyl-, methyl ester(27720-05-4)
• EPA Substance Registry System: L-Phenylalanine, N,N-dimethyl-, methyl ester(27720-05-4)

Safety Data

• Hazardous Substances Data: 27720-05-4(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 17469-89-5 (2S)-2-(dimethylamino)-3-phenylpropanoic acid 
• 50-00-0 formaldehyd 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 74-88-4 methyl iodide 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 

Downstream Products

• 1350524-92-3 2-(2-(dimethylamino)-3-phenylpropanoyl)-N-phenylhydrazinecarbothioamide 
• 97800-69-6 2-(dimethylamino)-3-phenylpropanehydrazide 
• 19881-91-5 (1-benzyl-2-hydroxy-ethyl)-trimethyl-ammonium; iodide 
• 56755-22-7 L-N,N,N-trimethylphenylalanine 
• 103-25-3 3-phenylpropanoic acid methyl ester 
• 27720-03-2 S-2-(Dimethylamino)-3-phenyl-1-propanol 

Relevant articles and documents

Expedient Synthesis of N-Methyl- and N-Alkylamines by Reductive Amination using Reusable Cobalt Oxide Nanoparticles

N-Methyl- and N-alkylamines represent important fine and bulk chemicals that are extensively used in both academic research and industrial production. Notably, these structural motifs are found in a large number of life-science molecules and play vital roles in regulating their activities. Therefore, the development of convenient and cost-effective methods for the synthesis and functionalization of amines by using earth-abundant metal-based catalysts is of scientific interest. In this regard, herein we report an expedient reductive amination process for the selective synthesis of N-methylated and N-alkylated amines by using nitrogen-doped, graphene-activated nanoscale Co3O4-based catalysts. Starting from inexpensive and easily accessible nitroarenes or amines and aqueous formaldehyde or aldehydes in the presence of formic acid, this cost-efficient reductive amination protocol allows the synthesis of various N-methyl- and N-alkylamines, amino acid derivatives, and existing drug molecules.

METHOD OF PRODUCING TERTIARY AMINE OR TERTIARY AMINE DERIVATIVE

PROBLEM TO BE SOLVED: To provide a method of producing tertiary amine or tertiary amine derivative with high selectivity. SOLUTION: In the method of producing tertiary amine or tertiary amine derivative, a reaction system including: an organic chemical raw material containing at least one kind of group selected from -NH2, -NH2 HCl, >NH and >NH HCl, a nitrogen atom contained in the group bounding to a carbon atom; aliphatic alcohol having 1 to 20 carbon atoms; and a catalyst where a carrier containing titanium oxide carries a silver component (metal silver or silver compound), is irradiated with light, and the group in the organic compound raw material is converted to -NR02 or >NR0, ( R0 is an aliphatic hydrocarbon group having 1 to 20 carbon atoms derived from the aliphatic alcohol). The percentage content of the silver in the catalyst is 0.5 to 10 mass% with respect to the titanium oxide. COPYRIGHT: (C)2015,JPOandINPIT

Amino acid based chiral N-amidothioureas. Acetate anion binding induced chirality transfer

N-Amidothioureas generated from amine-dimethylated natural l-phenylalanine and its d-enantiomer bearing a chiral carbon that is by 2 atoms or 3 chemical bonds away from the anion binding site establish chiral communication upon acetate anion binding to the thiourea moiety.