277319-62-7

Basic information

• Product Name: 4-AMINO-BENZAMIDE OXIME
• Synonyms: 4-Aminobenzamidoxime, 97%;4-AMino-N'-hydroxybenzene-1-carboxiMidaMide;Benzenecarboximidamide, 4-amino-N-hydroxy-
• CAS NO: 277319-62-7
• Molecular Formula: C₇H₉N₃O
• Molecular Weight: 151.17
• Product Categories: pharmacetical
• Mol File: 277319-62-7.mol
• Article Data: 9

Chemical Properties

• Melting Point: 168-170℃
• Boiling Point: 393.3°Cat760mmHg
• Flash Point: 191.7°C
• Appearance: /
• Density: 1.34g/cm³
• Vapor Pressure: 6.83E-07mmHg at 25°C
• Refractive Index: 1.631
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 6.84±0.69(Predicted)
• CAS DataBase Reference: 4-AMINO-BENZAMIDE OXIME(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-BENZAMIDE OXIME(277319-62-7)
• EPA Substance Registry System: 4-AMINO-BENZAMIDE OXIME(277319-62-7)

Safety Data

• Hazard Codes: T
• Statements: 25-42/43
• Safety Statements: 22-36/37-45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 277319-62-7(Hazardous Substances Data)

Usage

Description

4-amino Benzamidoxime is a synthetic intermediate useful for pharmaceutical synthesis.

InChI:InChI=1/C7H9N3O/c8-6-3-1-5(2-4-6)7(9)10-11/h1-4,11H,8H2,(H2,9,10)

Upstream product

• 873-74-5 4-Aminobenzonitrile 
• 619-72-7 4-nitrobenzonitrile 

Downstream Products

• 864680-71-7 3-(4-aminophenyl)-4,5-dihydro-1,2,4-oxadiazol-5-one 
• 10185-68-9 4-(5-methyl-1,2,4-oxadiazol-3-yl)-aniline 
• 1160931-81-6 2-(5-((5-(4-chlorophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)-N-(4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)acetamide 
• 17329-27-0 2-(4-aminophenyl)quinazoline-4(3H)-one 
• 3858-83-1 p-aminobenzamidine 
• 861536-16-5 N-(4-aminophenyl)cyanamide 

Relevant articles and documents

A cascade process for directly converting nitriles (RCN) to cyanamides (RNHCN) via SO2F2-activated Tiemann rearrangement

A simple, mild and practical process for the direct conversion of nitriles to cyanamides was newly discovered and exhibited a wide substrate scope as well as great functional group-tolerability (36 examples). In this efficient strategy, the in situ generated amidoximes obtained from the reaction of nitriles with hydroxylamine subsequently underwent Tiemann rearrangement, producing the corresponding cyanamides with great isolated yields under SO2F2. Additionally, the control experiments reportedly shed light on the tentative mechanism involved in the formation and elimination of the key intermediate: a sulfonyl ester.

Synthesis method for benzamidine derivatives

The invention discloses a synthesis method for benzamidine derivatives. According to the synthesis method disclosed by the invention, a reaction of preparing benzamidine derivatives from benzonitrile raw materials is completed in a green and efficient manner by using an ionic liquid-supported nano-metal catalyst, and the catalyst is high in activity and recoverable. Benzamidoxime is formed from benzonitrile and hydroxylamine hydrochloride, and then benzamidine is obtained through hydrogenation reduction under the catalysis of the ionic liquid-supported nano-metal catalyst.

Practical synthesis of N -substituted cyanamides via tiemann rearrangement of amidoximes

A facile and general synthesis of various N-substituted cyanamides was accomplished by the Tiemann rearrangement of amidoximes with benzenesulfonyl chlorides (TsCl or o-NsCl) and DIPEA.