277324-22-8Relevant articles and documents
Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity
Zbinden, Katrin Groebke,Banner, David W.,Hilpert, Kurt,Himber, Jacques,Lave, Thierry,Riederer, Markus A.,Stahl, Martin,Tschopp, Thomas B.,Obst-Sander, Ulrike
, p. 5357 - 5369 (2008/02/07)
The discovery of a highly potent and selective tissue factor/factor VIIa inhibitor is described. Upon oral administration of its double prodrug in the guinea pig, a dose-dependent antithrombotic effect is observed in an established model of arterial throm