27771-06-8Relevant articles and documents
Catalytic asymmetric alkylation of α-cyanocarboxylates and acetoacetates using a phase-transfer catalyst
Nagata, Kazuhiro,Sano, Daisuke,Shimizu, Yu,Miyazaki, Michiko,Kanemitsu, Takuya,Itoh, Takashi
scheme or table, p. 2530 - 2536 (2010/03/31)
The catalytic asymmetric alkylation of α-cyanocarboxylates and acetoacetates with an alkyl halide was performed under phase-transfer conditions to afford compounds which have a chiral quaternary carbon with up to 97% and 94% ee, respectively. As applicati
Efficient enantioconvergent synthesis of (S)-α-benzyl-α-methyl-β-alanine from (R)- and (S)-2-cyano-2-methyl-3-phenylpropanoic acid
Badorrey, Ramon,Cativiela, Carlos,Diaz-de-Villegas, Maria D.,Galvez, Jose A.,Gil, Ana
, p. 2209 - 2214 (2007/10/03)
An efficient synthesis of (S)-α-benzyl-α-methyl-β-alanine in 59% overall yield from benzaldehyde and methyl cyanoacetate has been developed. Enantioconvergent approaches to the synthesis of the target α,α-disubstituted β-amino acid from both enantiomers o
