27805-84-1Relevant articles and documents
Total Synthesis and Stereochemical Revision of Phacelocarpus 2-Pyrone A
Ronson, Thomas O.,Burns, Michael J.,Voelkel, Martin H. H.,Evans, Kieren J.,Lynam, Jason M.,Taylor, Richard J. K.,Fairlamb, Ian J. S.
, p. 18905 - 18909 (2015)
The first total synthesis of phacelocarpus 2-pyrone A is reported. The original natural compound was tentatively assigned (by NMR spectroscopy) as containing two cis-alkenes and a trans-vinyl ether connected to a 2-pyrone ring motif. Our computational pre
JAK kinase inhibitor, preparation method thereof, and application in the field of medicines
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Paragraph 0155-0158, (2019/04/10)
The application relates to a JAK kinase inhibitor, a preparation method thereof, and an application in the field of medicines and belongs to the field of medical chemistry. In the application, a series of novel small-molecular JAK inhibitors are provided and are represented as the general formula (II). The compounds have better effects and higher safety in prevention or treatment on JAK-related adaptation diseases.
JAK1 SELECTIVE INHIBITOR AND USES THEREOF
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Paragraph 0176, (2015/05/05)
The invention relates to the use of a JAK1 kinase-selective inhibitor that has minimal inhibitory activity towards Jak2 kinase for treating a disease, such as an inflammatory disease (e.g., moderate to severe Rheumatoid Arthritis) and/or bone loss, either