27876-19-3

Basic information

• Product Name: 4-(butan-2-yl)pyridine
• Synonyms: 4-sec-Butylpyridine; pyridine, 4-(1-methylpropyl)-
• CAS NO: 27876-19-3
• Molecular Formula: C₉H₁₃N
• Molecular Weight: 135.2062
• Mol File: 27876-19-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 198.4°C at 760 mmHg
• Flash Point: 67°C
• Density: 0.906g/cm³
• Vapor Pressure: 0.507mmHg at 25°C
• Refractive Index: 1.49
• CAS DataBase Reference: 4-(butan-2-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(butan-2-yl)pyridine(27876-19-3)
• EPA Substance Registry System: 4-(butan-2-yl)pyridine(27876-19-3)

Safety Data

• Hazardous Substances Data: 27876-19-3(Hazardous Substances Data)

Upstream product

• 536-75-4 4-Ethylpyridine 
• 74-96-4 ethyl bromide 
• 1113-78-6 tri(sec-butyl)borane 
• 1120-87-2 4-bromopyridin 
• 50720-05-3 indolyl acetyl chloride 
• 671795-46-3 sec-butylmagnesium bromide 
• 134305-08-1 2-[2-(2,2-Diethoxy-ethyl)-3-methyl-pentyl]-[1,3]dioxolane 
• 84355-18-0 4-sec-Butyl-1-(tert-butyl-dimethyl-silanyl)-1,4-dihydro-pyridine 
• 82126-19-0 4-s-butyl-1-ethoxycarbonyl-1,4-dihydropyridine 
• 110-86-1 pyridine 
• 63755-30-6 N-ethoxycarbonylpyridinium chloride 
• 84355-14-6 N-tert-butyldimethylsilylpyridinium triflate 
• 21101-88-2 3-methylpentanenitrile 
• 135351-37-0 2-(2,2-Diethoxy-ethyl)-3-methyl-pentanenitrile 

Relevant articles and documents

Synthesis and utility of dihydropyridine boronic esters

When activated by an acylating agent, pyridine boronic esters react with organometallic reagents to form a dihydropyridine boronic ester. This intermediate allows access to a number of valuable substituted pyridine, dihydropyridine, and piperidine products.

A NOVEL 1,2-ALKYL MIGRATION OF TRIALKYL(4-PYRIDYL)BORATES

The reaction of lithium trialkyl(4-pyridyl)borates with Lewis acids or acylating agents produced 4-alkylpyridines via 1,2-alkyl migration from boron to pyridine ring.

REGIOSELECTIVE SYNTHESIS OF 4-ALKYLPYRIDINES VIA 1,4-DIHYDROPYRIDINE DERIVATIVES FROM PYRIDINE

N-Ethoxycarbonylpyridinium chloride (1) reacted with at 4-position with almost complete regioselectivity (better than 99percent) to afford the corresponding 1,4-dihydropyridine derivatives (2) in high yields (81 ca. 94percent).The dihydropyridines were readily oxidized by oxygen to give 4-alkylpyridines (4:38 ca. 68percent yields).