27921-48-8

Basic information

• Product Name: 3-BENZYLTHIOPHENE
• Synonyms: 3-BENZYLTHIOPHENE
• CAS NO: 27921-48-8
• Molecular Formula: C₁₁H₁₀S
• Molecular Weight: 174.2621
• Product Categories: Thiophenes
• Mol File: 27921-48-8.mol
• Article Data: 42

Chemical Properties

• Boiling Point: 262.603 °C at 760 mmHg
• Flash Point: 81.703 °C
• Appearance: /
• Density: 1.101 g/cm³
• Vapor Pressure: 0.018mmHg at 25°C
• Refractive Index: 1.597
• CAS DataBase Reference: 3-BENZYLTHIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BENZYLTHIOPHENE(27921-48-8)
• EPA Substance Registry System: 3-BENZYLTHIOPHENE(27921-48-8)

Safety Data

• Hazardous Substances Data: 27921-48-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H10S/c1-2-4-10(5-3-1)8-11-6-7-12-9-11/h1-7,9H,8H2

Upstream product

• 872-31-1 3-Bromothiophene 
• 100-39-0 benzyl bromide 
• 498-62-4 3-thiophene carboxaldehyde 
• 108-86-1 bromobenzene 
• 27921-49-9 4-benzyl-thiophene-2-carboxylic acid 
• 188290-36-0 thiophene 
• 100-44-7 benzyl chloride 
• 185329-74-2 phenyl(thiophen-3-yl)methyl acetate 
• 98-80-6 phenylboronic acid 
• 100-51-6 benzyl alcohol 
• 140-11-4 Benzyl acetate 
• 71637-34-8 3-hydroxymethyl-thiophene 
• 102871-39-6 phenyl(thiophen-3-yl)methanol 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 146695-25-2 7-(4-Benzyl-thiophen-2-yl)-7-oxo-heptanoic acid ethyl ester 
• 144313-85-9 7-(3-Benzyl-thiophen-2-yl)-7-oxo-heptanoic acid ethyl ester 
• 184040-72-0 2-chlorosulfonyl-3-benzylthiophene 
• 337459-24-2 3-benzyl-2,5-dibromothiophene 
• 142422-55-7 7-(4-benzyl-2-thienyl)heptanoic acid 
• 142422-70-6 7-(3-benzyl-2-thienyl)heptanoic acid 
• 1393444-78-4 3-((4-(tert-butyl)phenyl)(phenyl)methyl)thiophene 
• 1097828-62-0 (2,5-dibromothiophen-3-yl)(phenyl)methanone 
• 941609-28-5 2,5-dibromo-α-phenyl-3-thiophenemethanol 
• 6453-99-2 3-benzoylthiophene 
• 185329-74-2 phenyl(thiophen-3-yl)methyl acetate 

Relevant articles and documents

A SO2F2 mediated mild, practical, and gram-scale dehydroxylative transforming primary alcohols to quaternary ammonium salts

A simple, practical and gram-scale process for direct transformation of primary alcohols or silyl ethers to ammonium salts was developed. This method has the feathers of easy work-up (a simple filtration), mild condition, high yield, great practicality and robustness. And the application of the ammonium salts in Suzuki coupling reaction was also accomplished.

Construction of Di(hetero)arylmethanes Through Pd-Catalyzed Direct Dehydroxylative Cross-Coupling of Benzylic Alcohols and Aryl Boronic Acids Mediated by Sulfuryl Fluoride (SO2F2)

A practical Pd-catalyzed direct dehydroxylative coupling of (hetero)benzylic alcohols with (hetero)arylboronic acids for the constructions of di(hetero)arylmethane derivatives under SO2F2 was described. This new method provided a strategically distinct approach to di(hetero)arylmethane derivatives from readily available and abundant benzylic alcohols under mild condition.

Cross-Coupling of Phenol Derivatives with Umpolung Aldehydes Catalyzed by Nickel

A nickel-catalyzed cross-coupling to construct the C(sp2)-C(sp3) bond was developed from two sustainable biomass-based feedstocks: phenol derivatives with umpolung aldehydes. This strategy features the in situ generation of moisture/air-stable hydrazones from naturally abundant aldehydes, which act as alkyl nucleophiles under catalysis to couple with readily available phenol derivatives. The avoidance of using both halides as the electrophiles and organometallic or organoboron reagents (also derived from halides) as the nucleophiles makes this method more sustainable. Water tolerance, great functional group (ketone, ester, free amine, amide, etc.) compatibility, and late-stage elaboration of complex biological molecules exemplified its practicability and unique chemoselectivity over organometallic reagents.